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MRCS last minutes > Surgical oncology > Flashcards

Surgical oncology Flashcards

1
Q

Eg of Growth factor oncogenes

A

Sis

erb-B

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2
Q

Eg of Transcription factor oncogenes

A

Myc

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3
Q

RET

A

Receptor tyrosine kinase oncogene

MEN IIA and IIB

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4
Q

Src

A

Cytoplasmic tyrosine kinase oncogene

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5
Q

Ras

A

Regulatory GTPases

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6
Q

Tumour suppressor genes

A

p53
BRCA 1 & 2
APC

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7
Q

Oncovirus : Epstein-Barr virus

A

Burkitt’s lymphoma
Hodgkin’s lymphoma
Nasopharyngeal carcinoma
Post transplant lymphoma

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8
Q

Oncovirus : Human Papilloma Virus 16/18

A 
Cervical cancer
Anal cancer
Penile cancer
Vulva cancer
Oropharyngeal cancer
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9
Q

Oncovirus : Human Herpes virus 8

A

Kaposi’s sarcoma

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10
Q

Extravasation of TPN

A

Hyaluronidase solution

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11
Q

Histological features of Malignancy

A 
Loss of differentiation
Disordered growth pattern
Variability in cell size
Variability in nuclear size
Increased mitotic activity
High nuclear:cytoplasmic ratio
Abnormal nuclei may be muiltiple
Abnormal chromatin pattern
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12
Q

Carcinogen : Asbestos

A

Mesothelioma

Carcinoma of the bronchus

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13
Q

Retinoblastoma ( Familial cancer $ )

A

Rb1 mutation
Retinoblastoma
OSteosarcoma

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14
Q

von Hipple-Lindau

A

RCC
Phaeochromocytoma
Haemangioblastoma

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15
Q

Polycyclic aromatise hydrocarbons in Soot / Chimney sweeps

A

Scrotal cancer

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16
Q

Tar

A

Skin cancer

17
Q

Aromatic amines : Beta-naphthylamines

Used in due and rubber industry

A

Bladder cancer

18
Q

Vinyl chloride exposure : PVC industry

A

Angiosarcoma of liver

MRCS last minutes (7 decks)

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