Surgery - Kidney Transplant Flashcards
functions of the kidney
blood pressure control, water balance, electrolyte balance ,acid base balance
hypotension and sepsis lead to which type of renal failure
a.pre renal
b.renal
c.post renal
a.pre renal
hypertension and diabetes lead to which type of renal failure
a.pre renal
b.renal
c.post renal
b.renal
prostatic enlargement and bladder obstruction lead to which type of renal failure
a.pre renal
b.renal
c.post renal
c.post renal
who is assessed for a kidney transplant
all with renal failure
all within first 6 months of dialysis are potential candidates
class 1 HLA tissue type means HLA is expressed on all nucleated cells which of these groups make up class 1
a.A and DR
b.A and B
c.DR and b
b.A and B
class 2 HLA tissue type means HLA is expressed on APCs and lymphocytes which of these groups make up class 2
a.A and DR
b.A and B
c.DR and b
d.DR
d.DR
Which of these indicates a complete HLA mismatch and so the pt immune system will make antibodies against the new kidney
a.000
b.111
c.222
c.222
HLA compatibility is calculated by mismatches
HLA antobodies can only be formed by…
transplant
transfusion
pregnancy
contraindications to kidney transplant
immunosuppression - sepsis, malignancy
over 80 yrs old
active renal disease
obesity
risks of kidney transplant
infection due to immunosuppression
non funciton
delayed function
rejection
graft thrombosis (sudden dip in urine output)
aa- painless oliguria
vv-painful oliguria
doppler ultrasound needed to check perfusion of kidney
a sudden dip in urine output indicates what complication of a kidney transplant
a.post transplant lyphoproliferative disorder
b.donor infection transfer of cmv
c.delay in function
d/non function
e.graft thrombosis
e.graft thrombosis
patients need to be checked for which virus prior to kidney transplant
a.ebv
b.cjd
c.cmv
d.herpes simplex
c.cmv
is detected on pcr
can cause fever, graft Injury and rejection and tissue invasion
post transplant lymphoproliferative disorder is a side effect of ..
a.immunosupression
b.transplantation
c.cmv infection
a.immunosupression
combination of infection and malignancy driven by Epstein Barr virus
if donor +ve and recipient -Ve
leads to fever , weight loss and lymphadenopathy
CT then biopsy
treatment - immunosupresssion decrease and rituximab
ptld is driven by which virus
a.ebv
b.cjd
c.cmv
d.herpes simplex
a.ebv
causes fever , weight loss, lymphadenopathy
