summary from rafi fc Flashcards
A band
myosin + overlapping actin
H band
within A, actin doesnt reach
I band
actin which isnt part of A
epimysium
whole muscle
perimysium
single fasicle
endomysium
single muscle fibres
simple synovial joint
one pair of articular surfaces
what are chondrocytes responsible for
EC matrix of hyaline cartillage T2
what causes septic arthriits
staph aureus
how to treat septic arthits
_ in a child
fluclox
child < 5 + cefriaxone for H. influenza / kingella cover
which bugs cause OM
mycoplasma, pseudomonas, salmonella, brucella (goat’s milk)
how to treat NF
penicillin + clindamycin
process behind DMD
alterations in anchorage of actin skeleton to basement membrane (fibres weakend without attachemnt)
what is enchondroma associated with
olliers + maffuci
what actually is enchondroma
hyaline cartilage arising in medullary cavity
what is LEMS
assoc with muscle weaenss + small cell carcinoma
arises from antibodies against Ca channels, causing reduced Ca entry + this reduced ACh vesicle release (which is needed to initiate muscle cell)
A nociceptor
fast / initial pain
C nociceptor
second / aftermath pain
what does spinothalamic tract do
pain perception (where it is and how bad)
what does spinoreticular tract do
autonomic / emotional response = fear of pain
what does carbimazepine do
blocks Na channels, useful of neuromytonia
anti phospholipid antibodies
anticardiolipin
lupus anticoagnulant
anti beta 2 glycoprotein
what actually is sjrogens
autoimmune destruction of exocrine glands
RO and LA
what actually are systemic sclerosis
autoimmune inflammation + thickening due to increased collagen deposition
what are the symptoms of limited systemic sclerosis
CREST
calconosis, raynauds, eosophageal dysmotility, sclerodactyl, talangectasia
antibodies of poly / dermatomyosisits
anti jo 1
ANA
treatmnet of polymyalgia rheumatica
15mg predisolone
is there muscle weakness in dermatomyosiits
no muscle weakness
SLE gene
HLA DR3
type of reaction of SLE
T3
antibody for SLE
anti - smith (very specific)
symptoms of GCA
carotid bruit
symptoms of polyarteritis nodosa
vessel bifurcation , hep B
how to treat large vessel vasculitis
40-60mg predisolone
GPA panca or canca
cANCA
symptoms of GPA
saddle nose
middle aged men
palpable purpura
how does methotrexate work
folate antagonist
what is spondylolisthesis
forward slippage of one vertebrae onto another
what is spondylolysis
defect in pars interarticulars of vertebrae
pain going down stairs?
PCL
what is OA dissecans
an area of the surface of the knee loses its blood supply + cartilage, sometimes causing bone to fragment off
what is pes cavus
fixed plantar flexion of the forefoot
tendinitis
inflammation resulting from microtears
tendinosis
degeneration of collagen from chronic overuse