summary from rafi fc Flashcards
A band
myosin + overlapping actin
H band
within A, actin doesnt reach
I band
actin which isnt part of A
epimysium
whole muscle
perimysium
single fasicle
endomysium
single muscle fibres
simple synovial joint
one pair of articular surfaces
what are chondrocytes responsible for
EC matrix of hyaline cartillage T2
what causes septic arthriits
staph aureus
how to treat septic arthits
_ in a child
fluclox
child < 5 + cefriaxone for H. influenza / kingella cover
which bugs cause OM
mycoplasma, pseudomonas, salmonella, brucella (goat’s milk)
how to treat NF
penicillin + clindamycin
process behind DMD
alterations in anchorage of actin skeleton to basement membrane (fibres weakend without attachemnt)
what is enchondroma associated with
olliers + maffuci
what actually is enchondroma
hyaline cartilage arising in medullary cavity
what is LEMS
assoc with muscle weaenss + small cell carcinoma
arises from antibodies against Ca channels, causing reduced Ca entry + this reduced ACh vesicle release (which is needed to initiate muscle cell)
A nociceptor
fast / initial pain
C nociceptor
second / aftermath pain
what does spinothalamic tract do
pain perception (where it is and how bad)
what does spinoreticular tract do
autonomic / emotional response = fear of pain
what does carbimazepine do
blocks Na channels, useful of neuromytonia
anti phospholipid antibodies
anticardiolipin
lupus anticoagnulant
anti beta 2 glycoprotein
what actually is sjrogens
autoimmune destruction of exocrine glands
RO and LA
what actually are systemic sclerosis
autoimmune inflammation + thickening due to increased collagen deposition
what are the symptoms of limited systemic sclerosis
CREST
calconosis, raynauds, eosophageal dysmotility, sclerodactyl, talangectasia
antibodies of poly / dermatomyosisits
anti jo 1
ANA
treatmnet of polymyalgia rheumatica
15mg predisolone
is there muscle weakness in dermatomyosiits
no muscle weakness
SLE gene
HLA DR3
type of reaction of SLE
T3
antibody for SLE
anti - smith (very specific)
symptoms of GCA
carotid bruit
symptoms of polyarteritis nodosa
vessel bifurcation , hep B
how to treat large vessel vasculitis
40-60mg predisolone
GPA panca or canca
cANCA
symptoms of GPA
saddle nose
middle aged men
palpable purpura
how does methotrexate work
folate antagonist
what is spondylolisthesis
forward slippage of one vertebrae onto another
what is spondylolysis
defect in pars interarticulars of vertebrae
pain going down stairs?
PCL
what is OA dissecans
an area of the surface of the knee loses its blood supply + cartilage, sometimes causing bone to fragment off
what is pes cavus
fixed plantar flexion of the forefoot
tendinitis
inflammation resulting from microtears
tendinosis
degeneration of collagen from chronic overuse
mallet toe
DIP fixed
hammer toe
PIP fixed
what is cellulitis caused by
B-haemolytic strep + staph
1st line investigation for roataor cuff pathology
USS
osteochrondroma chance of malignancy
1% change of malignant transformation
what does enchondroma look like on xray
leucent but can undergo mineralisation with a patchy sclerotic appearance
what does osteoid ostemoa look like on xray
small nidus of immature bone surrounded by an intense sclerotic halo
what is brodies abscess
subacute OM, lyitc lesion on xray
malignancy rate of osteosarcoma
10% have pulmonary mets at diagnosis
which defect of colalgen is osteogenesis imperfecta
T1
how to treat transient synovitis
NSAIDS
what is most common cause of child hip pain
transient synovitis
what happens in impingement syndrome
tendons of rotator cuff are compressed in the tight acromium space during movement - producing pain
how to treat impingement syndrome
subacromial decompression
DAB
dorsal interossei - abduction
PAD
palmar inteossei - adduction
definition of a knee dislocation
rupture of all ligaments
nerve and artery at risk in a shoulder dislocation
axillary nerve + artery
how to repair recurrent dislocations
bankart lesions
what is at risk in a humeral shaft fracture
radial nerve + brachial artery
what is a high risk with a scaphoid fracture
ANV
what are the 2 intracapsular fractures
femoral head and femoral neck
what are the 2 extracapsular fractures
intertrochanteric
subtrochanteric
which is worse intra or extra capsular
intra
compression injury salter harris 4
intraarticular salter harris 3+5
where do simple bone cysts arise from
growth defect from the physis
most common place to find osteosarcoma
knee
seropositive arthritiis
RA lupus scleroderma vasculitis sjrogens
seronegative arhtiris
anky spondyl
psoriatic
reactive
enteric
mixed CTD antibody
anti-RNP
myositis antibody
anti jo 1
back change in ankyl spondy
increased thoracic kyphosis
xray changes on anky spondyl
sclerosis / fusion of SI joints
syndesmophytes
bamboo spine
treatment for ankyl spondyl
NSAIDS
physio
anti-TNF
crystals in pseudogout
calcium pyrophosphate
what does chondrocalcinosis mean
depositino of calcium pyrophosphate crystals in cartilage in absence of acute inflammation
are complement levels high or low in SLE
low
what is the process behind sjrogens
excess collagen deposition
does PR pain improve with movement
yes
what is a poor prognostic factor of PM
dysphagia
which treatment for fibromyalgia
amitriptaline + gabapentin
age of GCA
> 50
how to treat ANCA +
IV steroids + cyclophsophamide (immune suppressor)
is HSP ANCA + or -
negative
which Ig is associated with HSP
IgA
what actually happens in DDH
dislocaiton / subluxation of femoral head during perinatal period
what is perthes
idiopathic osteochondritis of the femoral head causing necrosis + abnormal growth
boys 4-9
what is SUFE
pain in knee
treatment for SUFE
pin femoral head to avoid slippage
nerve at risk in hip joint problems
obturator nerve
what kind of meniscal tear is bucket handle
longitudinal
what test to do for meniscal tear
steimanns
treatment for hallux ridigus
arthrodesis
allerviates pain but reduced motion
where does the tibialise tendon insert into
navicular bone
investigatoin for cauda equina
urgent MRI to determine level of prolapse
disectomy follows
which probelms is carpal tunnel assocaited with
RA pregnancy diabetes renal fialure colles fracture
tinnels test
percussion over median nerve
phalens test
upside down prayer
in proximal humeral fractures, which way does the humeral shaft displace
medially due to the pull of pectoralis major
what is a nighstick fracture
fracture of ulnar shaft
what is bartons frcature
intra articular fratcure of distal radius where carpal bones sublux
how many degrees of angulation can be tolerated in a boxers fracture
45
which nerve damage can be caused by proximal tibia lfracture
common fibular nerve
common fibular nerve damage does
foot drop
what is a pilon fracture
distal tibial fracture (intraarticular)
what is a lisfranc fracture
fracture of the base of 2nd metatarsal with/without dislocation of the other metatarsals at the TMJ