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DNA syn. inhibitors > sulfonamides > Flashcards

sulfonamides Flashcards

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Biology 101 flashcards
1
Q

Short acting

A

Sulfisoxazole (6 hrs)
Sulfadimidine (4 – 8 hrs)
Sulfamethiazole (9 hrs)
admin ki sox meti main gir gaye

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2
Q

Intermediate acting

A

Sulfadiazine (10 hrs)
Sulfamethoxazole (10-12 hrs)
Sulfapyridine (upto 14 hrs)
pyramide ka design famous ha

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3
Q

Long acting

A 
Sulfadoxine (7-9 days)
Sulphamethoxypyridazine
Sulphadimethoxine
Sulphaphenazole
phenyl song ker ox metha hu giya
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4
Q

Poorly absorbed by GIT

A 
Sulphathalidine
Succinylsulphathiazole
Sulphaguanidine
Sulfasuxidine
thymine guanine uridine thiazide
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5
Q

For Topical Application

A

Sulphacetamide -ophthalamic
Silver sulfadiazine- less toxic - burns
Mafenide acetate - absorbed from burn site
inhibit CA - met. acidosis

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6
Q

Miscellaneous group

A

Sulfasalazine

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7
Q

Sulfamethoxazole & Trimethoprim

A

septran

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8
Q

Absorption

A

rapid -oral
stomach
small intestine

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9
Q

peak plasmsa h. life

A

2-6 hrs

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10
Q

distribution

A

all body fluids +placenta

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11
Q

plasma binding p

A

variable

displace other drugs +bilirubin

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12
Q

other routes

A

topical

IV - cotrimoxazole + na salt +5%dextrose sol.

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13
Q

therapeutic conc.

A

40-100microg/ml

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14
Q

met.

A

liver

acetylation - amino group

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15
Q

solubility

A

alkaline pH

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16
Q

adjustment

A

renal failure

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17
Q

spectrum

cat entered in new nostalgia

A 
g+ - g- bact.
staphylococci
streptococci
catarrhalis - chlamydia
n. gonorrhea
enterococci + enterobacter + e. coli
influenza
pneumocystis pneumonia
norcardia
toxoplasmosis - treponema pallidum
plasmodium
18
Q

MOA

A

competitively inhibit dihydropteroate synthase

bacteriostatic

19
Q

resistance

A 
dec. influx drug
overproduction -PABA
dec. affinity; plasmid
exogenous source
rickettsia not affected
anaerobes poor activity
20
Q

UTI

A

Sulfisoxazole

21
Q

Inflammatory bowel disease

Ulcerative colitis, regional enteritis

A

Sulfasalazine

22
Q

Tropical sprue

poorly absorbed

A

Sulfasuxidine
sulfaguanidine
sulfasalazine

23
Q

Ocular infections

A

sulfacetamide

24
Q

Burn infections

A

topical

25
Q

Rheumatoid Arthritis

A

Sulfasalazine

26
Q

toxoplasmosis

A

Sulfadiazine + Pyrimethamine

27
Q

Nocardiosis

A

Sulfisoxazole

Sulfadiazine

28
Q

Sulfamethoxazole + trimethoprim

A 
h. influenza
moraxella catarrhalis
immunocompromised - aeromonas hydrophila
pneumocystis pneumonia
sepsis g-
nocardiosis
backup - cholera - typhoid fever - shigellosis
MRSA
l. monocytogenes
29
Q

Karan placed seven new photos AT bed

A 
kernicterus
displacement of drug - warfirin albumin
steven johnson syn.
phototoxicity
aplastic anemia
thrombocytopenia
blood disorders G6PD hemolysis
30
Q

trimethoprim

A

inhibit dihydrofolate reductase

31
Q

absorption

A

highly lipophilic

well

32
Q

distribution

A

well

BBB placenta vaginal fluidprostate

33
Q

plasma protein binding

A

65-70%

34
Q

met.

A

urine

60 % in 1 hr

35
Q

IV

A

na salt
5% dextrose
60-95%

36
Q

use

A

UTI

with sulphamethexole

37
Q

Ratio of Trimethoprim & Sulfamethoxazole

A

1:5

38
Q

So plasma ratio becomes

higher vd of trimethoprim

A

1:20

39
Q

half life

A

both drugs same

10-11hrs

40
Q

RESISTANT ORGANISMS

A

Psudomonas ariginosa
Bacteroids fragalis
Enterococci

41
Q

toxic effects

A

similar to sulfonamides

adverse effects in AIDS patients

DNA syn. inhibitors (1 decks)

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