Structure of Haemoglobin Flashcards
1
Q
Describe Haemoglobin
A
- tetramer
- 2 pairs of unlike chains
2
Q
How many amino acids to alpha-chains have?
A
141 amino acids
3
Q
How many amino acids to B, y & g chains have ?
A
146 amino acids
4
Q
How are alpha helices stabilised?
A
H-bonding
- each globin chain has 8 helical segments
5
Q
What kind of spiral does 80% of amino acids form?
A
Right Handed spirals
- a- Helix = 3.6 amino aicds per turn
6
Q
Describe the addition of haem to the tertiary structure
A
- imparts stability to tertiary structure
- haem loss results in unfolding of chain & loss of helical content
7
Q
How does Haem fit into the tertiary structure ?
A
fits into a non-polar pocket & held in position by amino acids
8
Q
What are some symptoms of haemoglobin deficiency ?
A
- can be sensitive to light
- darkened uring
- skin blisters
- abnormal hair growth
