Stomach and Small Bowel Flashcards
GIST DDX
- adeno, leiomyosarcoma, leiomyoma, lymphoma,NET
GIST HPI?
GIB, stomach pain, obstructive sx
GIST PE, TEST, Imaging?
- PE- abdominal mass, lymphadenopathy
- Test
- EGD-submucosal mass, bx (not always defines dx)
- EUS-heterogenous, cont c gastric wall, without lymphadenopathy
- FNA-spindle cells (not always necessary (bleed or spreads)however indicated for mets dz for chemo, neoadj therapy, lymphoma suspected
- Imaging
- large hypervascular, exophytic, heterogenous, central necrosis
GIST imaging characteristics? Path?
- Imaging
- large hypervascular, exophytic, heterogenous, central necrosis
- Path
- IMHC-KIT rec tyrosine kinase CD117
GIST treatment
Surgery for resectable gist, margin negative 1 cm, segmental resection, partial gastric resection (BII gastrojejunal recon),en bloc, GEJ then total gastrectomy with RNY, lymphadenectomy usu unneeded
GIST Neoadj chemo?
Imantib (Gleevac) to downsize it if >5 cm or more 5-10 mitosis/HPF needed or sunitib if resistant
GIST surgery?
- Surgery
- abdominal exploration
- enter lesser sac to eval extent
- assess wedge vs formal BII
- resect 1 cm margins
GIST notes?
- Dont percutaneous Biopsy -avoid seeding or tumor rupture
- Note- mets go to liver and peritoneum
- adjuvant gleevac therapy
What is Mallory Weiss?
Linear tear in mucosa of gastric cardia not painful if painful think Boarhaaves (pacnreatitis, chemo etc)
MAllory Weiss treatment?
Resuscitate while doing history
Mallory Weiss HPI, Hx, PE, Labs
- HPI- vomiting, retching, and hemetemesis,
- Hx-HH, binge drinking or portal HTN
- PE- check for crepitance, neck and mediastinum and check for peritonitis
- Labs- check coags, and T&C
Dx Mallory Weiss? and Treatment?
- Dx- Endoscopy
- 90% self healing
- Tx
- 1st- hemoclip, heater probe, epi injection
- 2nd- Angio (Left gastric, splenic branches, inferior phrenic arteries) especially with comorbidities
- 3rd-if needed gastrostomy high and oversew with locking suture (anterior 3-0 PDS) pack anterior and posterior with lap pads to find bleeder
- if portal HTN add octreotide
- consider Vasopressin
- Note- No blakemoretube cuz this is arterial bleeding and usu associated with hiatal hernia
Gastric ulcer ddx?
DDx- gastric cancer, PUD
Gastric Ulcer HPI, Hx, PE, Labs?
- HPI- Epigastric pain, dyspepsia, vomiting,dark stools, anemia, weight loss
- Hx- ETOH, NSAID
- PE-Vitals, rigid abdomen, rectal exam (heme positive, Blummer’s shelf)
- Labs- CBC, serial H&H, T&C , electrolytes check for Acholorhydria (related to cancer)
How to test for H. Pylori?
- How to test for H. Pylori
- biopsy antrum most accurate
- Serum Ab of h pylori
- Stool test to confirm eradication
- Urea breath test- stop PPI , pep to-bismal, abx for 2 weeks, swallow something with urea if h pylori is present converts the urea into Carbon dioxide detected from your exhaled breath after 10 minutes
Gastric Ulcer types?
- Note-
- Type 1- Lesser curve
- Type 2- Included duodenum and acid
- Type 3- Prepyloric and acid
- Type 4 -GE junction
Gastric Ulcer Dx?
- Dx-
- abdominal xray to r/o free air
- +/- Barium UGI
- Endoscopy biopsy center and around the edges close to 10 biopsies
- defines the ulcer
- brushings increase sensitivity of biopsies
- bx the pylorus for H. Pylori
- May need to repeat EGD in 6-8 weeks for a chronic ulcer, tx med, repeat egd if improving
Gastric ulcer Treatment?
- Benign- PPI,H2 Blockers, Sulcrafate ETOH and Smoking, NSAID Cessation
- Benign with H Pylori- PPI, Amoxicillin, Clarithromycin, Pepto-Bismol
- after tx check urea breath test for eradication repeat tx if+
- Most ulcers heal with 12 weeks
- repeat endoscopy 6-12 weeks depending how large and scary it was
- Fails to heal after 8 weeks consider ZES, cancer
- check gastrin level >1000 and pH
Gastric ulcer surgery indications?
- Surgery indications
- IHOP
- Intractibility >3 cm unlikely to heal, fail 24 wks to heal if bx benign the surgery based off location
- Note on tech- antrectomy is falling a little out of favor for a wedge resection and for 2-3 adding an acid reducing sx)
Surgery type 1 gastic ulcer?
Type 1 - Antrectomy to include ulcer (goblet cells on duodenal side indicates adequate resection) recon with BI make sure frozens neg for malignancy. 2% recurrence
Surgery type 2 gastic ulcer?
Type 2-3 -Antrectomy and Vagotomy
Surgery type 3 gastic ulcer?
Type 2-3 -Antrectomy and Vagotomy
Surgery type 4 gastic ulcer?
- Type 4-
- Option 1- Antrectomy and suture bx the ulcer and leaving it in situ and checking response
- Option 2- Csendes’ (subtotal gastrectomy with RNY jejunal reconstruction) remember just an ulcer, procedure to remove ulcer (long oblique line extending from the greater curvature to the right of the EGJ using free hand tech and cutting under direct vision without compromising the lumen at the EGJ, then creating a long oblique gastrojejunostomy
Gastric ulcer with hemorrhage?
- Hemorrhage (3 diff vs a PUD) 1-always bx 2-angio can be attempted 3- threshold to operate is lower (4-6 uPRBC)
- 10% mortality, GDA, Visible vessels high rate of bleed
- resuscitate patient prior
- EGD + bx +/- angiogram with vasopressin
- Surgery
- if > 4u prbcs and w/in 48 hrs of endoscopic intervention or rebleed
- Type 1 - Antrectomy to include ulcer
- Type 2-3 -Antrectomy and Vagotomy
- Type 4-5 - gastrostomy bx ulcer and oversewn and biopsy antrum
- If unstable - performa wedge resection or suture/biopsy ulcer plus vagotomy/pylorplasty if 2-3
Gastric ulcer with obstruction?
- Obstruction from gastric ulcer
- need to treat hypokalemic hypochloremic metabolic acidosis (H/Na exchange in prox tubule and K/H in distal tubule c aciduria)
- Antrectomy and BI or BII reconstruction
Gastric ulcer with perforation?
- Perforation
- 24hrs and unstable
- biopsy ulcer and graham patch
- 24hrs and unstable
gastric ulcer postop and follow up?
- Postop
- NPO, IVF, NGT, ABX, Foley cath, PPI, H.pylori tx
- POD 5 Gastrograffin and if negative start clears and ADAT
- Upper endoscopy in 12 weeks to reevaluate the tx
Gastric cancer ddx?
- ddx- benign esophagitis, gastritis, PUD, varices
- malignant- gastric or esophageal ca, MALT, Lymphoma, GIST
Gastric cancer sx, RF, PE, Labs?
- ddx- benign esophagitis, gastritis, PUD, varices
- malignant- gastric or esophageal ca, MALT, Lymphoma, GIST
- Sx- epigastric pain, dysphagia, black stools, weight loss
- RF- Smoking, ETOH, Elderly, H. Pylori, Achlorhydria, Pernicious, Previous gastric resection
- PE- rectal blumers shelf node, supraclavicular/periumbilical LN, abdominal mass, surgical scars, ,
- Labs- HGB, Prealbumin
Gastric ulcer work up? Risk stratified? Notes?
- dx,stage, preop, tx
- Work Up
- CT
- CT- hepatic mets, lymphadenopathy, ascites, extension
- CT chest if GEJ
- EUS and FNA,
- PET (PET changes tx options 20%)
- MRI
- Laparoscopy
- CT
- Risk stratified-nutritional, cv, pulm
- Notes
- Lap dx mets catches 30% of mets not seen on CT scan, peritoneal fluid,
- R status
- RO neg margins, R1 micro residual dz, R2 gross residual dz
- Lymph nodes
- R1- imed adj perigastric LN
- R2- LN along roots of gastric vessels
- R3- Porta hepatis nodes + SMV nodes and retropanc LN
- En-bloc resection of adjacent organs (spleen, tail of pancreas, kidney except pancreas and CBD
Gastric ulcer treatment? Tis,TI, local regional advanced? mets?
- combined modality tx
- early Tis, T1 (mucosa) gastrectomy c D1/D2 lymphadenectomy
- Local regional advanced resectable-
- neoadjuvant and then surgery 5 cm margins
- mets-
- palliative dep on sx and functional status
- place a feeding jejunostomy in obstructing GE jxn mass
- Palliative chemo, laser recanulization, dilation, stenting
- surgical bypass has fallen out of favor
Gastric cancer adjuvant therapy?
adjuvant chemo RO rsxn t3,T4 positive nodes Etoposide, cisplatin, 5 FU
Gastric cancer treatment in proximal, middle, distal tumors?
- Location
- proximal tumors (upper 1/3)-
- total gastrectomy (nothing less) c RNY esophagojejunostomy & frozen sections
- Middle third or in corpus
- subtotal gastrectomy or total gastrectomy depending on size of tumor
- distal tumors (lower third)-
- radical subtotal gastrectomy involving 3 cm of duodenum, hepatogastricomentum, greater omentum, and DI resection (immediate adjacent perigastric LN)
- subtotal gastrectomy c B2 or RNY recon
- Palliation- total gastrectomy not gastroenterostomy!
- proximal tumors (upper 1/3)-
Describe a subtotal gastrectomy c RNY for gastric cancer?
- Subtotal Gastrectomy c RNY DI resection (supra and infrapyloric LN and along greater and lesser curves)
- supine incase of right thoracic or cervical approach
- laparoscopy exploration catches 30% mets not seen on CT scan
- Palpate liver
- Dissect omentum from L transverse colon
- Mobilize Left colon from spleen (resect spleen if involved)
- Lift stomach and determine if involves transverse mesocolon
- Biopsy celiac node and if negative may proceed with resection for cure
- Biopsy porta hepatis
- determine if possible to resect with 5 cm margins
- Dissect along greater curvature of stomach to 5 cm margin from tumor and mobilize
- Kocherize duodenum and divide using GIA taking care to avoid retained antrum
- Dissect along port hepatic toward celiac axis to take all nodal tissue
- divide L gastric at its origin and nodal tissue is swept from crus and hiatus
- Proximal splenic artery is dissected along superior border of pancreas and nodal tissue is taken so splenic hilum
- Subtotal gastrectomy - divide proximal stomach with GIA
- Total gastrectomy - encircle esophagus with penrose, control c satinsky clamp and transect
- send proximal margins for frozen
- reconstruct c RNY gastro or esophagojejunostomy (D1 resection)
- Adjuvant chemoradiation is questionable f(5FU and (radiation decreases recurrence))
- feeding J
- drains to the stump and EJ anastomosis check amylase and bilirubin
- NGT beyond GJ anastomosis
Palliative gastrectomy?
Palliative gastrectomy - very controversial - if patient able to eat probably no reason, if bleeding or obstructive than consider
gastric cancer postop?
- Post op
- small meals, B12, iron
- No adjuvant chemo after surgery
gastric cancer curveballs
- Curveballs- its actually esophageal cancer- Ivor lewis resection
- hepatic mets-dont resect
how does gastric lymphoma present
mass or gastric folds
first bx of gastric lymphoma comes back and nonspecific what next?
- rescope the patient and get more bx and H.Pylori status
if gastric lymphoma persist after h pylori treatment?
radiation
gastric lymphoma work up?
Bone marrow bx and CT scans H/N/C/A
gastric lyphoma - Stage I or II treatment?
resect c LN,Liver should be biopsied and a splenectomy if grossly involved
postop gastric lymphoma?
- chemo
- if low grade MALT - just H Pylori tx
Gastric Carcinoid hx, and notes?
- Fx- MEN I, Heart problems, Carcinoid Sx
- Note- sporadic, associated c pernicious anemia, ZES
gastric carcinoid test?
- Test- Octreotide scan search for other lesions on GI track
- CT scans
- 24 hr urine 5HIAA, Chromogramin A sensitive
- gastrin and calcium
gastric carcinoid types?
- Note-Sporadic can be malignant and need 2 cm margins
- Note- pernicious anemia usually benign and are multiple small and antrectomy to reduce gastrin levels will cause regression of carcinoid usually
gastric carcinoid 1cm and different gastrin?
- Tumor 1 cm or normal gastrin (more aggressive) or atypical cells
- Gastrectomy with D1 dissection (cancer operation)
gastric carcinoid liver mets treatment?
- Liver mets- treat c chemo embolization, RFA, resectiond
Post gastrectomy issues, early problems, days?, sx? imaging, treatment?
- Early problems
- Leak-
- POD 3-5, Tachycardic, abd pain, SOB
- CT and UGIS
- Stable and no sepsis small fluid- perc drain, NPO, TPN, ABX
- Septic or s/o peritonitis - reexplore, oversew, place drains, feeding J tube
- Early few days post op Doudenunal stump leaks
- check tissue healthy, friable, necrotic?
- healthy- oversew hole, graham patch vs pursestrings 16 french cath doudenum
- Ischemic- - debride to healthy tissue, resuture, buttress c momentum, place catheter in duodenum laterally for decompression, widely drain area
- Friable- place lateral duodenal tube, buttress c omentum, widely drain, drain stomach with gastrojejunostomy, feed J tube
- Leak-
- Bleeding-
- from staple line usually stops, check coags, if doesn’t stop reexplore and suture ligation, possible arteriogram
- Obstruction
- afferent limb ( has the blind limb)- decompress endoscopically place NGT into limb
- efferent limb (Enteral limb) - NGT trial
- internal hernia- reexplore correct defect mesocolic, mesenteric, Petersons defect
- Gastroparesis- NGT, TPN, Pro motility agents give 6-8 weeks to improve
post gastrectomy problems that are Late?
Dumping, post vagotomy diarrhea, marginal ulcer, duodenal stump leak, gastroparesis, bile gastritis
Dumping syndrome dx, treatment?
- Dumping Syndrome
- Dx - gastric emptying studies, serial glucose measurements
- Octreotide, high fiber diet, decreased liquids c meals generally improves
- Roux limb recon or takedown of loop gastrojejunostomy
- Post vagotomy Diarrhea (not related to eating)
- cholestyramine and lomotil (usually resolves it)
- if fails convert BI —>BII or gastrojejunostomy
- Doudenal stump leak POD 10 ?
- Doudenal stump leak POD 10
- usually see abscess or mass mixed c fluid in RUQ after surgery
- perc drain , NPO, TPN allow 6-12 wks to control fistula and allow hopefully to close
gastroparesis treatment?
- Gastroparesis
- promotility agent
- Surgery
- gastric resection (antrectomy if didn’t do before)
- subtotal gastrectomy c BII or RNY recon
Bile gastritis treatment?
- Bile Gastritis (confirm c hepatobiliary scan), by biopsy, alkaline drop test important that you get the dx correct
- caused by eliminating the pyloric sphincter
- post prandial, burning epigastric pain
- meds don’t really help
- if severe RNY recon c roux limb 45-60 cm in length