SSc, Polymyositis, Dermatomyositis Flashcards
Calcinosis Raynauds Esophageal involvement (+gut dysmotility) Sclerodactyl Telangectasia
face hands and feet
pulmonary hypertension
Anti-centromere
The whole body
Lung
Cardiac
GI
Renal
Echocardiogram
spirometry
Anti-topoisomerase-1 (40%) (aka Scl70)
anti-RNA polymerase
increases the risk of renal crisis
AKI
Accelerated hypertension
ACEi
A2RBs
Stop smoking
Reactive hyperaemia (the worst!)
Nifedipine
Sildenafil
IV prostacyclin
sympathectomy
cyclophoshamide
cartilage
Pinna
nasal septum
larynx (stridor)
T
insidious
striated
proximal
dysphonia
Dysphagia
paraneoplastic
Skin involvement
Shawl sign (back and shoulders)
Eyelids (lilac-purple with oedema)
Knuckles (papules, also elbows knees)
Interstial
also breathing difficutlies due to muscle damage
Myocarditis
Muscle biopsy
ALT AST Aldolase CK LDH
Anti-Mi2
Anti-Jo1
Screen for malignancy. It can be paraneoplastic.
Prednisolone
immunosuppresives (aziathiproine/methe/cyclophos)
Hydroxychloroquine
tacrolimus
calcium