sodium-glucose co-transporter

Question 1

re-absorption of glucose

Answer 1

takes placce in the proximal convoluted tubule mediated by the sodium- glucose co-transporters (SGLT-1 AND SGLT-2) which is normally 100% efficient
- glucose only appears in the urine in plasma concentration exceeds the transport maximum which is around 11mmol/litre

Question 2

SGLT-1 is mainly expressed in both

Answer 2

the intestine and the PCT but SGLT-2 is exclusive to the proximal convoluted tubule,

Question 3

SGLT-2 IS MAINLY PRESENT IN WHAT PART OF PCT

Answer 3

FIRST PART OF THE PROXIMAL CONVOLUTED TUBULE

Question 4

SGLT-1 IS MAINLY PRESENT IN WHAT PART OF THE PCT

Answer 4

THE LATER APRT OF THE PROXIMAL CONVOLUTED TUBULE

Question 5

SGLT-2 INHIBITORS

Answer 5

E.G EMPAGIFLOXIN AND DAPAGLIFLOZIN ARE COMPETITIVE INHIBITORS OF SGLT-2 CUASING A DIRECT GLYCSURIA