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Question 1

Modern drug design is based on two general approaches

Answer 1

ligand-based drug design (LBDD) and structure-based drug design (SBDD)

Question 2

steps of SBDD

Answer 2

1) starget 3D structure analysis
2) the identification of a potentially druggable pocket

Question 3

biophysical methods of binding site
identification

Answer 3

fragment screening, site-directed muta
genesis, etc.

Question 4

computational methods for ligand-binding site identification

Answer 4

geometry-based (Fpocket4), similarity-based (ProBiS5), computer vision-based (DeepSite,6 BiteNet7)

Question 5

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