Shit you must know cold Flashcards
EGF
- source
- function
EPIDERMAL GROWTH FACTOR
Source:
- Activated Macrophages
- Salivary Glands
- Keratinocytes, etc.
Functions:
- STIMULATES FORMATION OF GRANULATION TISSUE
- Mitogenic (induce proliferation) for Keratinocytes and Fibroblasts
- Stimulates Keratinocyte Migration
VEGF
- source
- function
VASCULAR ENDOTHELIAL GROWTH FACTOR
Source:
- Mesenchymal Cells
Functions:
- Stimulates Endothelial Cell Proliferation
- Increases vascular Permeability
PDGF
- source
- function
PLATELET-DERIVED GROWTH FACTOR
Source: (pretty much every cell in inflammation)
- Platelets
- Macrophages
- Endothelial Cells
- Smooth m.
- Keratinocytes
Function:
- Chemotatic Factor for neutrophils, macrophages, fibroblasts, smooth muscle cells
- ACTIVATES AND SIMULATES PROLIFERATION of fibroblasts, endothelial and other cells
- STIMULATES ECM Protein synthesis
TGF-ß
- source
- function
TRANSFORMING GROWTH FACTOR
Source:
- Fibroblasts
Function:
- stimulates migration and proliferation, INCREASED SYNTHESIS of COLLAGEN and fibronectin and DECREASED degradation of ECM due to inhibition of metalloproteases
*****Most Important Cytokine for the Synthesis and Depositino
Which ligands bind to Receptors with intrinsic tyrosine kinase activity?
- how do these receptors carry out signaling?
Growth Factors (EGF, VEGF, FGF, HGF)
- Ligand binds on one chain and receptor activates tyrosine kinase on the other chain
Which ligands bind to G protein coupled receptors?
- how do these receptors carry out signaling?
Inflammatory Mediator and Hormoles, ALL chemokines
- you should know how a GPCR works
Which ligands bind to receptors without intrinsic enzymatic activity?
- how do these receptors carry out signaling?
Many cytokines (intererons, growth hormone, CSF, EPO)
- JAK-STAT style receptors
FGF
FIBROBLASTIC GROWTH FACTOR
- Important for angiogenesis in wound healing
What is the role of TGF-ß in wound healing?
- Stimulates production of Collagen, Fibronectin, and Proteoglycans, and Inhibits Collagen Degradation
***Limits and Terminates Inflammatory Response
What is the role of PDGF in wound healing?
- Migration and Proliferation of Fibroblasts and smooth muscle cells
- May contribute to migration of Macrophages
What is the role of FGF in would healing?
Angiogenesis
What is the are the main factors driving remodeling of scar tissue?
Building up:
-TGF-ß
Tearing Down:
- Metalloproteases (zinc dependent)
Static:
- TIMP inhibition of metalloproteases
