Serotonin Flashcards

1
Q

what is the full name of serotonin?

A

5-hydroxytryptamine

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2
Q

what is the precursor of 5HT?

A

l-tryptophan

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3
Q

how many serotonin receptors and groups are there?

A

14 receptors in 5 groups

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4
Q

what are the 5 groups of serotonin receptors?

A
5HTR1
5HTR2
5HTR3
5HTR6/7/4
5HTR3
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5
Q

what is SERT?

A

serotonin transporter

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6
Q

what are 5 drugs which affect the presynaptic reuptake of serotonin?

A
para-chlorophenylalanine
reseperine
SSRIs
para-chlorophetamine
receptor (ant) agonists
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7
Q

what are four therapeutic uses of drugs targeting 5HT synapses?

A

depression
schizophrenia
migraine
nausea and vomiting

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8
Q

what are four biological functions of serotonin?

A

hunger
pain perception
anxiety
depression

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9
Q

how is serotonin implicated in the hunger function?

A

implements ‘hunger state’ in zebrafish and in humans, serotonin is involved in feeding and appetite

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10
Q

how is serotonin implicated in pain perception?

A

serotonin neurons exhibit a phasic response to footshocks and so they play a role in coding aversive stimuli

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11
Q

how is serotonin implicated in anxiety?

A

dampens mPFCs response to vHPC input
if serotonin levels are higher, there is increased inhibition of presynaptic VHC input onto paremetal cells and therefore lower anxiety levels

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12
Q

how is serotonin implicated in depression?

A

tryptophan-depletion has been linked to the onset of depressive episodes.
also depression is linked to a reduction of serotonin in the neocortex

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