Salivary Glands Flashcards

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1
Q

salivary glands have what type of secretory portions?

A

compound tubuloacinar

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2
Q

minor salivary glands arise from?

A

ectoderm and endoerm- week 12

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3
Q

sublingual glands arises from

A

endoderm- wk 8

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4
Q

parotid gland arises from

A

ectoderm - wk 6

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5
Q

submandibular glands arise from

A

endoderm-week 6-7

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6
Q

parotid anlagen develops where?

A

near corners of stomodeum- develops from a groove like invagination of ectoderm in the crease between the maxillary and mandibular swellings

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7
Q

sublingual anlagen develops where?

A

develops from buds in the sulcus surrounding the sublingual folds on the floor of the mouth. Lateral to the submandibular primordia

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8
Q

submandibular anlagen develops where?

A

bilaterally from bud in the sulcus surrounding sublingal folds in the floor of the mouth.
-cords grow posterior and lateral to the tongue

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9
Q

myoepithelial cells arise from

A

neural crest cells

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10
Q

2 ways the parotid unique

A
  1. intragladular lymph nodes

2. epithelial buds grow, branch and extend around the facial nerve but parotid is not innervated by the facial nerve

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11
Q

in canalization, where to the lumens first appear?

A

proximal by the oral epithelium and the distal

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12
Q

when does the first cleft form?

A

stage 3-initiation of branching in the terminal parts of epithelial cord

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13
Q

what surrounds each acini?

A

myoepithelial cells?

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14
Q

in cytodifferentiation what 3 things can the terminal bulbs become?

A

acini, myoepithelial cells, duct cells

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15
Q

branching requires what for this to occur?

A

collagen type 3

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16
Q

what type of collagen provides support and maintains the structure?

A

type 1 and 4

17
Q

what secretes collagen type 3?

A

fibroblasts

18
Q

what inhibits n-linked glycosylation ?

A

tunicamycin

19
Q

what does tunicamycin interfere with?

A

interferes with calcium which inhibits cleft formation and localized cell proliferation= no branching.

20
Q

need ______ to make to ECM. the ECM contains ______ which initiates branching in the terminal parts of the epithelial cord

A

fibroblasts

collagen type 3

21
Q

what growth factor regulates branching

A

EFG

22
Q

how is FGF important?

A

stalk elongation

23
Q

what does treatment with hyaluridontase do to the basal lamina?

A

disrupts basal lamina, calcium interference, inhibits cleft formation and local cell proliferation

24
Q

what induces the oral epithelium to form a bud

A

mesenchyme induces proliferation in epithelium

25
Q

what is a reason you would not form a salivary gland?

A

disrupt the basal lamina

26
Q

what causes the cells of the glands to form tight junctions?

A

mechanoreceptors on epithelial cells sense the increased hydrostatic pressure from the secretion of presumptive duct cells

27
Q

what is involved in the positioning of the glands?

A

BMP signaling and HOX genes