Rod Dunbar 1 Flashcards
1
Q
What are the 10 cancer cell properties?
A
Sustaining proliferative signalling Evading growth suppressors Activating invasion and metastasis Enabling replicative immortality Inducing angiogenesis Resisting cell death Genome instability and mutation Tumour promoting inflammation Avoiding immune destruction Deregulating cellular energetics
2
Q
What is the importance of fundamental characteristics of the HannaWeinburg framework for cancer cells?
A
Even though there are many different DNA changes observed in cancers, these changes often involve changes in the same kinds of functions and the same kind of molecules therefore this framework can help organize the thinking about cancer
3
Q
What is the difference between monoclonal and polyclonal tumours?
A
Monoclonal tumours arise from a single progenitor cell while polyclonal tumours have different distinct DNA lineages in the tumour cell
