Rheumatoid Arthritis - Flusser

Question 1

Which diseases are associated with:

HLA-B51?

HLA-DR4?

Answer 1

B51:

Behcet’s disease

DR4:
Rheumatoid Arthritis

Question 2

What are the hallmark changes of rheumatoid arthritis seen in X-Rays?

Answer 2

Juxta-articular osteoporosis

Loss of cartilage

Erosion

Narrowed joint

Changes can be seen within one year

Question 3

In which diseases is positive RF factor seen?

Answer 3

1. Connective tissue disease:
   rheumatoid arthritis, Sjogren’s syndrome, SLE, progressive systemic sclerosis (PSS), MCTD, systemic sclerosis (SS)
2. Acute viral illnesses:
   Infectious mononucleosis, hepatitis, influenza
3. Parasitic infection:
   Typanosomiasis, malaria, etc.
4. Chronic inflammatory disease:
   TB, leprosy, syphilis, SBE (Subacute Bacterial endocarditis)
5. Neoplasms
6. Hypergammaglobulinemia:
   Cryoglobulinemia, chronic liver disease, sarcoid
7. Pulmonary diseases:
   Pulmonary fibrosis and others
8. Increases with age

Question 4

What are the 3 different deformities in fingers and toes seen in rheumatoid arthritis?

Answer 4

Question 5

Where are the locations of action of Abatacept, Retuximab and Etanercept in the release of inflammatory factors in the immune system (picture)?

Answer 5