Retroviruses Flashcards
Retroviruses contains which two viruses?
Oncoviruses and Lentiviruses
What are the characteristics of Retroviruses?
Enveloped, +ssRNA genome
Reverse transriptase to synthesize DNA from RNA
DNA integrates into host cell DNA
What are the two forms of Oncoviruses?
HTLV-1 and HLTV-II
What does HTLV stand for?
Human T-Lymphotropic virus
How is HTLV-I transmitted?
By sexual contact, contaminated blood, mother to child
What happens to someone infected with HTLV-I?
About 1 in 25 infected persons develop cancer as a result of infection
What are the 2 Lentiviruses?
1- SIV(Simian Immunodeficiency Virus)
2- HIV (Human Immune Deficiency Virus)
How many forms of SIV are there?
18 SIVs causing infection in 20 species
What did SIV give rise to?
HIV-1 and HIV-2
What are the 2 forms of SIV we need to know?
SIV cpz and SIV sm
Who has SIV cpz and is most closely related to what?
Chimpanzee strain of SIV and most closely related to HIV-1
How did HIV-1 arise?
Arose are SIV cpz was transmitted from chimps to humans
What is SIV sm from and what is it related to?
SIV from Sooty Mangabey and most closely related to HIV-2
How many types of HIV are there?
2
What are the general ways that HIV-1 and HIV-2 are distinguished?
genetically and antigenically