RENAL DISEASES PART 1 Flashcards
immune-mediated
GLOMERULAR
infection/toxic substances
TUBULAR
INSTERSTITTIAL
GLOMERULAR
- Acute Tubular Necrosis
- Fanconi’s Syndrome
- Nephrogenic Diabetes Insipidus
TUBULAR
- Urinary Tract Infection
- Acute Interstitial Nephritis
INSTERSTITTIAL
- Renal Calculi/Lithiasis
- Renal Failure
majority are of immune origin
GLOMERULAR DISEASES
exposure to chemicals and toxins
GLOMERULAR DISEASES
disruption of the electrical membrane charges
GLOMERULAR DISEASES
deposition of amyloid material from systemic disorders
GLOMERULAR DISEASES
basement membrane thickening
GLOMERULAR DISEASES
refers to a sterile, inflammatory process that affects the granules and is associated with the finding of blood, protein, and casts in the urine
glomerulonephritis
deposition of immune complexes, formed in conjunction of Group A Streptococcus infection on the glomerular membranes
- Acute PostStreptococcal Glomerulonephritis
Glomerulonephritis presenting as nephritic syndrome
- Acute PostStreptococcal Glomerulonephritis
deposition of immune complexes from systemic immune disorders (ex. SLE) on the glomerular membrane
- Rapidly Progressive/Crescentic Glomerulonephritis
crescentic – cellular proliferation of epithelial cells inside the bowman’s which forms crescents
- Rapidly Progressive/Crescentic Glomerulonephritis
Deposition of antiglomerular basement membrane antibody to glomerular and alveolar basement
- Goodpasteur Syndrome
Intial pulmonary complaints (hemoptysis)
- Goodpasteur Syndrome
Development of hematuria
Morphological changes: resemble rapidly progressive (crescentic)
- Goodpasteur Syndrome
Causes a granuloma-producing imflammation of the small blood vessels of primarily the kidney and respiratory system
- Wegener’s Granulomatosis
Dx: (+) Antineutrophilic cytoplasmic antibody (ANCA)
- Wegener’s Granulomatosis
Occurs only in children following viral respiratory infections
- Henoch Schonlein Purpura
Allergic purpura that causes decrease in the number of platelets and affects vascular integrity
- Henoch Schonlein Purpura
A pronounced thickening of the glomerular basement membrane resulting from the deposition of IgG immune complexes
- Membranous Glomerulonephritis
Seen in SLE, Sjogren’s syndrome, secondary syphillis, and hepatitis B infection
- Membranous Glomerulonephritis
Tendency to thrombosis
- Membranous Glomerulonephritis
Cellular proliferation affecting capillary walls or the glomerular basement membrane
- Membranoproliferative Glomerulonephritis
Gradual worsening of symptoms leading to loss of kidney function
- Chronic Glomerulonephritis
Progression to renal failure
- Chronic Glomerulonephritis
Symptoms:
Fatigue, anemia, hypertension, edema, and oliguria
- Chronic Glomerulonephritis
Many varieties of casts
- Chronic Glomerulonephritis
Markedly decreased GFR
- Chronic Glomerulonephritis
Increased BUN and CREATININE
- Chronic Glomerulonephritis
Electrolyte imbalance
- Chronic Glomerulonephritis
immune-mediated
- Nephritic Syndrome