relapsing polychondritis Flashcards
1
Q
what is the targeted autoAb?
A
type II collagen
2
Q
what is the HLA association?
A
HLA-DR4
3
Q
signs/symptoms
A
ears -> spares earlobes, can lead to cauliflower ear, and hearing loss
nose -> may lead to saddle nose deformity, decreased sense of smell
laryngeal/tracheal –> hoarseness, wheezing, risk of pneumonia
+ eye involvement or poly arthritis
4
Q
1 and #2 cause of death
A
1 Infection (Pneumonia) #2 vasculitis followed by arterial aneurysm, airway collapse, renal failure, malignancy
5
Q
what is the disease course?
A
chronic, recurrent episodes of inflammation with chondrolysis and structural collapse as cartilage is replaced by granulation tissue and fibrosis
6
Q
what is MAGIC syndrome?
A
relapsing polychondritis + behcet
7
Q
Tx
A
prednisone
