Regulation of vascular function

Question 1

autoregualtion is the link between…

Answer 1

blood flow and metabolism

Question 2

how does flow change in response to perfusion pressure?

Answer 2

abrupt increase or decrease in perfusion pressure will eventually return towards previous levels, this depend on the metabolic needs of the tissue.

Question 3

how does autoregulation differ around the body?

Answer 3

some vascular beds have tight regulation (cerebellar circulation) and some have almost none (skin)

Question 4

what is reactive hyperaemia

Answer 4

occurs after a blood vessel si occluded for a short period, when release BF rises above the pre-occlusion level andthis hyperaemia is maintained for a period roughly equivalent to the occluded period

Question 5

what is the myogenic hypothesis of autoregulation?

Answer 5

increased perfusion presure causes stretch of smooth muscle –> elicits smooth muscle contraction

Question 6

what is the metabloic hypothesis of autoregulation

Answer 6

as muscle works more (increased metabolism)

- increased metabolite release causes vasodilation, increased BF

Question 7

what role does the endothelium have in autoregualtion?

Answer 7

stretch causes stress on endothelium –> release of NO (vasodilator)

Question 8

definition of autoregulation

Answer 8

the tendency of an organ to maintain blood flow despite changes in perfusion pressure