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1
Q

3 stages of wound healing

A

inflammation, proliferation, tissue remodeling

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2
Q

What does the matrix region contain

A

keratin producing cells

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3
Q

what skin layer(s) does first degree burn go through

A

epidermis only

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4
Q

second degree burn

A

epidermis and dermis

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5
Q

what is the safest way to test for suspected peanut allergy in GP

A

IgE antibody testing

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6
Q

what is the alternative milk of choice for infants with cow’s milk allergy

A

extensively hydrolysed infant formula milk

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7
Q

what category of itch is scalp psoriasis

A

puritoceptive

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8
Q

prurigo nodularis is a result of what

A

chronic itch

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9
Q

type 2 hypersensitivity

A

direct cell killing

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10
Q

type 3 hypersensitivity

A

immune complex mediated

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11
Q

topical steroids are vasoconstrictive, true or false

A

true

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12
Q

what synthesises collagen

A

fibroblasts

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13
Q

what is porphyria cutanea tarda

A

painful, blistering skin lesions that develop on sunexposed skin

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14
Q

topical steroids are lipophilic, true or false

A

true

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15
Q

role of vitamin A

A

vital for epithelial proliferation, keratinisation and development

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16
Q

role of vitamin k

A

essential for several blood coagulation factors

17
Q

role of vitamin C

A

essential co-factor in collagen formation e.g. hair, and for bone and teeth health

18
Q

role of zinc

A

required for many metabolic pathways. required for structure and function of skin. Vital for wound healing

19
Q

is rice gluten free

A

yes

20
Q

what vasoactive substances do mast cells release

A

histamine, tryptase, heparin (all preformed) and leukotrienes, prostaglandins, cytokines including IL4 and TNF (all synthesised on demand)

21
Q

serious features of anaphylaxis

A

throat swelling, wheeze, increased resp rate, tachycardia, hypotension

22
Q

cells of the innate immune response

A

monocytes/macrophages, neutrophils , dendritic cells, basophils, mast cells, eosinophils, NK cells

23
Q

which immune system responds rapidly

A

innate

24
Q

which immune system is slow response

A

adaptive

25
Q

which immune system has memory

A

adaptive

26
Q

side effects of vitamin d analogues

A

hypercalcaemia, hypercalcuria

27
Q

side effects of topical steroids

A
  • thinning of skin
  • purpura
  • stretch marks
  • steroid rosacea
  • fixed telangiectasia
  • perioral dermatitis
  • may worsen or mask infections
  • systemic absorption (can cause adrenal suppression, cushing’s syndrome).
  • rebound and cause flare in diseases like psoriasis
  • glaucoma and cataract.
28
Q

people with freckles have one defective copy of which gene?

A

MC1R

29
Q

actinic lentigines (“liver spots” or “age spots”)

A

benign, small gray-brown spots on wrists, backs of the hands, forearms and face

30
Q

what is the medical name for common moles

A

melanocytic naevi

31
Q

What are actinic keratoses precursors of?

A

SCC

32
Q

what is subluxation?

A

partial dislocation, where the articular surfaces are displaced, but still overlap