Pulmonary Drugs MOA

Question 1

Methotrexate

Answer 1

Anti-inflammatory; Inhibits dihydrofolate reductase to prevent inflammatory cascase

Question 2

Hydroxychloroquine/Sulfasalazide

Answer 2

MOA unknown

Question 3

Leflunomide

Answer 3

Inhibits t-lymphocyes to stop inflammatory cascade

Question 4

TNF Antagonist

Answer 4

Prevents action of TNF to decrease inflammation

Question 5

Costimulation Modulators

Answer 5

Block T-cell signaling and activation

Question 6

Anti-CD20 Monoclonal Antibody

Answer 6

Causes B-lymphocyte depletion in bone marrow and synovial tissue

Question 7

Anti-Interleukin-6 Receptor Antibody

Answer 7

Blocks interleukin-6 which is implicated in joint damage and disease activity and anemia

Question 8

Targeted Synthetics

Answer 8

Inhibits specific kinases

Question 9

Acetaminophen (APAP)

Answer 9

Centrally acting analgesic and antipyretic; minimal anti-inflammatory

Question 10

NSAIDs

Answer 10

Has analgesic and antipyretic activities by blocking COX1 and COX2 causing inhibition of prostaglandins

Question 11

Colchicine

Answer 11

Anti-Inflammatory; Interferes w/migration of neutrophils to site of inflammation (urate crystal buildup)

Question 12

Allopurinol

Answer 12

Drug and primary metabolite (oxypurinol) reduce uric acid concentration by inhibiting xanthine oxidase

Question 13

Febuxostat

Answer 13

Xanthine oxidase inhibitor

Question 14

Probenecid

Answer 14

Uricosuric; blocks reabsorption of uric acid to increase its excretion

Question 15

Pegloticase

Answer 15

Recombinant form of uricase (enzyme that converts uric acid to excretory product)

Question 16

B2 Adrenergic Agonists

Answer 16

Relaxes airway smooth muscles by direct stimulation of B2 receptors in airway—increase mucus clearance and stabilizes mast cell

Question 17

Inhaled Anticholinergics

Answer 17

Anti-Inflammatory; inhibits effects of acetylcholine on muscarinic receptors in airway–>bronchodilation

Question 18

Methylxanthines

Answer 18

Anti-Inflammatory; bronchodilation by inhibiting phosphodiesterase and antagonizing adenosine

Question 19

Corticosteroids

Answer 19

Decreases airway inflammation by attenuating airway hyperresponsiveness, minimizes mucus production/secretion, and IMPROVES RESPONSE TO B2 AGONISTS

Question 20

Leukotriene Receptor Antagonists

Answer 20

Anti-inflammatory; Acts to antagonize the leukotriene receptor

Question 21

Immunomodulator

Answer 21

Anti-inflammatory; inhibits binding of IgE to receptors on mast cells and basophils

Question 22

Phosphodiesterase-4 Inhibitors

Answer 22

Reduces inflammation by inhibiting breakdown of cAMP (indirect bronchodilation)

Question 23

Cromolyn

Answer 23

Decreases bronchospasms through anti-inflammatory effect

Question 24

Bupropion SR

Answer 24

Antidepressant-blocks reuptake of dopamine and NE

Question 25

Varenicline

Answer 25

Nicotinic receptor partial agonist. Reduces cravings/blocks smoked nicotine