Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Pulmonary Drugs MOA > Flashcards

Pulmonary Drugs MOA Flashcards

1
Q

Methotrexate

A

Anti-inflammatory; Inhibits dihydrofolate reductase to prevent inflammatory cascase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Hydroxychloroquine/Sulfasalazide

A

MOA unknown

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Leflunomide

A

Inhibits t-lymphocyes to stop inflammatory cascade

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

TNF Antagonist

A

Prevents action of TNF to decrease inflammation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Costimulation Modulators

A

Block T-cell signaling and activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Anti-CD20 Monoclonal Antibody

A

Causes B-lymphocyte depletion in bone marrow and synovial tissue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Anti-Interleukin-6 Receptor Antibody

A

Blocks interleukin-6 which is implicated in joint damage and disease activity and anemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Targeted Synthetics

A

Inhibits specific kinases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Acetaminophen (APAP)

A

Centrally acting analgesic and antipyretic; minimal anti-inflammatory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

NSAIDs

A

Has analgesic and antipyretic activities by blocking COX1 and COX2 causing inhibition of prostaglandins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Colchicine

A

Anti-Inflammatory; Interferes w/migration of neutrophils to site of inflammation (urate crystal buildup)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Allopurinol

A

Drug and primary metabolite (oxypurinol) reduce uric acid concentration by inhibiting xanthine oxidase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Febuxostat

A

Xanthine oxidase inhibitor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Probenecid

A

Uricosuric; blocks reabsorption of uric acid to increase its excretion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Pegloticase

A

Recombinant form of uricase (enzyme that converts uric acid to excretory product)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

B2 Adrenergic Agonists

A

Relaxes airway smooth muscles by direct stimulation of B2 receptors in airway—increase mucus clearance and stabilizes mast cell

17
Q

Inhaled Anticholinergics

A

Anti-Inflammatory; inhibits effects of acetylcholine on muscarinic receptors in airway–>bronchodilation

18
Q

Methylxanthines

A

Anti-Inflammatory; bronchodilation by inhibiting phosphodiesterase and antagonizing adenosine

19
Q

Corticosteroids

A

Decreases airway inflammation by attenuating airway hyperresponsiveness, minimizes mucus production/secretion, and IMPROVES RESPONSE TO B2 AGONISTS

20
Q

Leukotriene Receptor Antagonists

A

Anti-inflammatory; Acts to antagonize the leukotriene receptor

21
Q

Immunomodulator

A

Anti-inflammatory; inhibits binding of IgE to receptors on mast cells and basophils

22
Q

Phosphodiesterase-4 Inhibitors

A

Reduces inflammation by inhibiting breakdown of cAMP (indirect bronchodilation)

23
Q

Cromolyn

A

Decreases bronchospasms through anti-inflammatory effect

24
Q

Bupropion SR

A

Antidepressant-blocks reuptake of dopamine and NE

25
Q

Varenicline

A

Nicotinic receptor partial agonist. Reduces cravings/blocks smoked nicotine

Pharmacology (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions