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Farmacologie > Prokinetice > Flashcards

Prokinetice Flashcards

1
Q

Indicatii prokinetice

A 
Tulburari motilitate GI
BRGE
Staza gastrica si duodenala
Diskinezii biliare
Gastropareza
Adjuvant in pregatirea pentru Rx contrast
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2
Q

Clase de prokinetice

A 
Antagonisti dopaminergici
M-colinomimetice
Modulatori ai R 5HT
Agonistii receptorilor pentru motilina
Alte mecanisme
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3
Q

Antagonisti dopaminergici - reprezentanti

A

Domperidon
Metoclopramid
Itoprid

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4
Q

Domperidon - mecanism

A

Blocarea R D2 si D3 -> creste motilitatea GI, creste pres SEI, grabeste golirea stomacului, creste peristaltismul duodenal

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5
Q

Domperidon - RA

A

Hiperprolactinemie

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6
Q

Metoclopramid - RA

A 
Tulb extrapiramidale reversibile - ! diskinezii tardive - ireversibile
HiperPRLemie
Sedare
Tk, palpitatii
Anxietate
Diaree
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7
Q

Metoclopramid - CI

A 
Condus autovehicule
Hemoragie digestiva, obstructie intestinala, perforatie intestinala
Feocromocitom (+ eliv CA din MSR)
Epilepsie, tratament cu neuroleptice
Tratament prelungit (>3-4 luni)
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8
Q

Colinomimetice - reprezentanti

A

Neostigmina

Piridostigmina

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9
Q

Neostigmina - mecanism de actiune

A

Blocarea reversibila a acetilcolinesterazei -> + RM -> + motilitatea digestiva

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10
Q

Neostigmina - indicatii

A

Ileus post-op/post-partum

Miastenia gravis

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11
Q

Neostigmina - RA

A

Hipersalivatie
Colici
Bronhospasm

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12
Q

Neostigmina - CI

A

Astm bronsiv
Obstructie mecanica TGI / TGU
Boala Parkinson

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13
Q

Prucaloprid - clasa de medicamente

A

Modulatori ai R 5HT

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14
Q

Prucaloprid - mecanism de actiune

A

+ specific R 5HT4, favorizeaza transmit colinergica -> creste peristaltismul colic

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15
Q

Agonisti ai R pentru motilina

A

ATB macrolide - eritromicina, azitromicina, claritromicina

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16
Q

Dexloxiglumid

A

antagonist al R CCK1 -> + evacuarea gastrica

I: gastropareza, SII (constipatie

Farmacologie (8 decks)

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