Primary Immune Deficiencies Mechanisms

Question 1

What are the steps in Innate immunity?

Answer 1

Production of mature granulocytes

Recruitment to site of infection

Recognition of pathogen

Enodocytosis/ Opsonisation

Killing Via Phagolysosome

Question 2

What are the steps in adaptive immunity?

Answer 2

Production of B and T cells

Maturation of B and T cells

Function of T cells

B cell activation/ Isotype switching via CD4 T cells

Question 3

Which primary immune deficiency inhibits the production of mature granulocytes?

Answer 3

Reticular Dysgenesis
Kostmann Syndrome
Cyclic neutropenia

Question 4

Which primary immune deficiency inhibits phagolysosomes?

Answer 4

Chronic Granulomatous Disease

Question 5

Which primary immune deficiency inhibits the production of T and B cells?

Answer 5

Reticular Dysgenesis
X linked SCID
ADA deficiency

Question 6

Which primary immune deficiency inhibits the maturation of B cells?

Answer 6

Brutons X linked Agammaglobulinaemia

Question 7

Which primary immune deficiency inhibits T cell function?

Answer 7

Bare Lymphocyte syndrome

Question 8

Which primary immune deficiency inhibits the maturation of T cells?

Answer 8

DiGeorge’s

Question 9

Which primary immune deficiency inhibits B cell maturation via CD4 stimulation?

Answer 9

Hyper IgM syndrome
Selective IgA deficiency
CVID

Question 10

Which primary immune deficiency inhibits recruitment?

Answer 10

Leukocyte Adhesion deficiency

Question 11

Which primary immune deficiency affects haematopoietic stem cells?

Answer 11

Wiskott Aldrich Syndrome