Potentially Malignant Disorders and Oral Cancer Flashcards
what is a potentially malignant lesion
altered tissue in which cancer is more likely to form
what is a potentially malignant condition
generalised state with increased cancer risk
name some potentially malignant oral conditions
lichen planus
oral submucous fibrosis
iron deficiency
tertiary syphilis
what version of lichen planus is more likely to be malignant
ulcerative or erosive
why is iron deficiency potentially malignant
atrophy of oral epithelium means the barrier function is diminished
what types of leukoplakia can be potentially malignant
chronic hyperplastic candidosis
proliferative verrucous leukoplakia
what are the 2 general types of potentially malignant lesions in the mouth
leukoplakia
erythroplakia
where does chronic hyperplastic candidosis occur
commissures
who gets chronic hyperplastic candidosis
smokers
what is chronic hyperplastic candidosis caused by
candida albicans
what do you need to do if you suspect chronic hyperplastic candidosis
take a biopsy
what takes of histology stains are needed for chronic hyperplastic candidosis
2 stains - H&E and PAS (periodic acid schiff)
what is seen on the H&E histology of chronic hyperplastic candidosis
excessive keratin formation where epithelium is generally non-keratinised
chronic inflammatory cells
microabscesses in upper layers
what would you see on the PAS histology of chronic hyperplastic candidosis
candida albicans hyphae
what is the treatment for chronic hyperplastic candidosis
systemic antifungal - fluconazole capsules 50mg once a day for 14 days
biopsy
smoking cessation
observe
what factors helps you predict whether a leukoplakia can become malignant
age and gender
idiopathic
site - floor of mouth and tongue
clinical appearance
what type of leukoplakia has the highest transformation rate
proliferative verrucous leukoplakia
what is seen on the histopathology of a leukoplakia turning malignant
dysplasia
atrophy of epithelium
candida infection