Population genetic tests for selection

Question 1

Why are population genetics needed?

Answer 1

• It’s not always clear what trait should be measured
• We need to rule out chance effect

Question 2

What does selective sweep mean

Answer 2

Strong positive selection of an advantageous variant passes off more offspring to the next generation

Question 3

What happened to the antimalarial drug, pyrimethamine

Answer 3

-The resistance spread to fixation in approximately 6 years
- Resistance induced by specific point mutations in parasite (chromosome 4)

Question 4

What does REHH stand for

Answer 4

Relative extended haplotype homozygosity

Question 5

What is Tajima’s D

Answer 5

Statistically significant departures from 0 suggest the action of other evolutionary forces

Question 6

What does Tajimas D measure

Answer 6

D compares the relative abundance of intermediate and low frequency variants
- If there’s excess of low frequency variants: D<0

Question 7

Whats the SLC24AF gene in humans

Answer 7

A non-synonymous SNP that influences differences in skin pigmentation levels between individuals of West African ancestry
-Ala111 is ancestral
-Thr111 is derived

Question 8

What does Fy*O do

Answer 8

Confers resistance to vivax malaria
- fixed in sub-saharan Africa but absent elsewhere