Platelet aggregation inhibitors

Question 1

How does clopidogrel aid in inhibiting platelet aggregation?

Answer 1

It blocks the receptor that allow ADP to enter the cell

Question 2

How does aspirin aid in inhibiting platelet aggregation?

Answer 2

It inhibits COX-1 and 2 = stops the formatinon of thromboxane A2.

Question 3

How does dipyridamole inhibit platelet aggregation?

Answer 3

Inhibits the breakdown of cyclin AMP (which reduces thromboxane A2 activity)

Question 4

Why are ADP, thromboxane A2 and cyclic AMP important in inhibiting platelet aggregation?

Answer 4

They are all important in the activation of the g-protein iib/iiia receptor. By blocking these factors we are preventing the formatinon of the dimer (receptor) that is fundamental in platelet aggregation.

Question 5

What is the aim by preventing platelet aggregation?

Answer 5

Prevent thrombus formation

Question 6

In what type of thrombosis are anti-platelet drugs like aspirin and clopidogrel used?

Answer 6

Arterial thrombosis - used in the treatment of NSTEMI