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Biochemistry > Plasma Proteins & Immunoglobulins > Flashcards

Plasma Proteins & Immunoglobulins Flashcards

1
Q

B1-globulin glycoprotein

A

Transferrin

  • 2 mols Fe per mol of Tf
  • Tfr1 and Tfr2 - receptors that bind iron to facilitate endocytosis
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2
Q

A2-globulin plasma protein

A

Ceruloplasmin

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3
Q

1 mole of ceruloplasmin binds __ atoms of copper VERY TIGHTLY

A

6

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4
Q

Transmembrane protein in enterocyte with ferroxidase activity

A

Hephaestin

  • Converts ferrous to ferric for transport across plasma membrane
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5
Q

Carries Fe across basolateral membrane

A

Ferroportin

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6
Q

Transfers iron from apical surface of enterocytes into their interiors

A

DMT1 (Divalent Metal Transporter)

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7
Q

Protein that stores iron (Fe3+, ferric) in enterocytes for future use

A

Ferritin

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8
Q

High Fe levels: Fe _______ to IRE-BP that ________ binding of IRE to mRNA, leading to synthesis of _______ and degradation of ________

A

High Fe levels: Fe BINDS TO to IRE-BP that PREVENTS binding of IRE to mRNA, leading to synthesis of FERRITIN (storage of iron) and degradation of TfR

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9
Q

Low Fe levels: Fe _______ to IRE-BP that ________ binding of IRE to mRNA, leading to synthesis of _______ and degradation of ________

A

Low Fe levels: Fe DOES NOT BIND to IRE-BP that ALLOWS binding of IRE to mRNA, leading to synthesis of TfR (Fe transport) and degradation of ferritin

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10
Q

Osmotic pressure % d/t albumin

A

80%

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11
Q

Major protein of human plasma

A

Albumin (60%)

  • NOT glycosylated
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12
Q

Plasma glycoprotein that binds extracorposcular Hb

A

Haptoglobin (Hb-Hp complex)

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13
Q

Half life of Hp

A

5 days

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14
Q

Half-life of Hb-Hp complex

A

90 mins

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15
Q

Plasma protein not synthesized in the liver

A

Gamma-globulins (membrane-bound polyribosomes)

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16
Q

Iron in enterocytes of proximal duodenum is in the (A) form due to the action of (B) enzyme

A

(A) ferrous state (Fe2+)

(B) ferrireductase

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17
Q

Copper is carried by (A) to liver and leaves the liver through (B)

A

(A) albumin

(B) ceruloplasmin

18
Q

Disorder with mutation in ATP7A gene

A

Menke’s disease

ATP7A gene - copper-binding P-type ATPase

19
Q

X-linked d/o of copper metabolism

A

Menke’s disease

20
Q

Kayser-Fleischer ring

A

Wilson’s disease

21
Q

Mutation in ATP7B gene

A

Wilson’s disease

ATP7B protein - copper-binding P-type ATPase

22
Q

Drug that chelates copper

A

Penicillamine

23
Q

Genetic disease wherein copper can’t be excreted from bile and accumulates in the liver, brain, kidney, and RBC

A

Wilson’s disease

Copper toxicosis

24
Q

Inhibits trypsin, elastase and certain protease

A

α1-antiproteinase

25
Q

Principal serine protease inhibitor of human plasma

A

α1-antiproteinase

26
Q

Deficiency in α1-antiproteinase has a role in which disease?

A

Emphysema

27
Q

Largest plasma glycoprotein

A

α2-macroglobulin

28
Q

Transports 10% of zinc

A

α2-macroglobulin

  • synthesized in monocytes, hepatocytes, and astrocytes
29
Q

Major member of plasma proteins that include complement proteins C3 and C4

A

α2-macroglobulin

30
Q

Panproteinase inhibitor that binds proteinases and cytokines

A

α2-macroglobulin

31
Q

Accumulation of various insoluble fibrillar proteins between cells of tissues

A

Amyloidosis

32
Q

Plasma Igs are specialized cells of the _______ lineage

A

B cell

33
Q

Plasma Ig: CONSTANT region of half of light chain positioned towards ______ end

A

Carboxyl

34
Q

Plasma Ig: VARIABLE region of half of light chain

A

Amino terminal

35
Q

Linkage in plasma Igs

A

Disulfide bonds

36
Q

Plasma Ig: VARIABLE region of heavy chain

A

1/4 in amino terminal

3/4 - heavy chain

37
Q

Functional regions of plasma Igs

A

2 Fab, 1 Fc

Fab - antigen-binding fragments
Fc - crystallizable fragment

38
Q

5 types of heavy chain regions determine the immunoglobulin class. What are the designated regions?

A

G, M, A, D, E

39
Q

All light chains are either ______ or ______ — never a mixture

A

Kappa or lambda

40
Q

Class-switching in Plasma Igs: Ab of ___ normally proceeds molecules of ___ class

A

IgM; IgG

41
Q

Downregulates intestinal absorption of iron from intestine, placental transfer, and release from macrophages

A

Hepcidin

Biochemistry (2 decks)

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