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Repro Flash Cards > Pharmacology Antibiotics/Misc > Flashcards

Pharmacology Antibiotics/Misc Flashcards

1
Q

Metronidazole MoA

A

inhibits protein synthesis in susceptible organisms when chemical structure is reduced

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2
Q

What do you use metronidazole for?

A

Trich
BV
DOC for anaerobes in intra-abdominal infection
C. diff, Giardiasis, Amebiasis

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3
Q

Common SE of Metronidazole

A 
Flushing
T wave flattening
aseptic meningitis
nausea
metallic tast
reversible neutropenia or thrombocytopenia
?? Carcinogenic
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4
Q

Contraindications for Metronidazole

A 
Sever liver dz
seizure hx
blood dyscrasia
CHF
severe renal dz
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5
Q

Common dx dx interactions of Metronidazole

A 
Ethanol (disulfiram-like rex)
Anticoagulants
Phenytoin
Phenobarbital
Lithium
Cimetidine
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6
Q

Monitoring for Methronidazole

A

LFT

CBC

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7
Q

Cetriaxone MoA is what?

A

in actively growing bacterial cells, interferes with transpeptidation of bacterial cell walls by binding pen binding protein (PCP)

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8
Q

Indications for Ceftriaxone are?

A 
Gonorrhea
Gram+, more Gram - coverage
Acute OM, sinusitis, LFTI
Meningitis
Empiric Rx of serious infections pending C and S
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9
Q

Common S/E with ceftriaxone

A

Rash
Diarrhea
Eosinophilia
Bacterial/fungal superinfection with prolonged use

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10
Q

What are contraindications for Ceftriaxone?

A

anaphylaxis to PCn

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11
Q

Dx Dx interactions for Cefriaxone

A

Warfarin

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12
Q

Azithromycin MoA

A

reversibly bins to 50S subunit of bacterial ribosome and inhibit protein synthesis

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13
Q

Azithromycin is used to treat what?

A

Chlamydia
Pcn substitute
Gonorrhea (+ceftriaxone)
CAP, PID, Acute OM, sinusitis, pharyngitis, COPD, Pertussis

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14
Q

Common S/E of azithromycin

A

Possible QT prolongation

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15
Q

Doxycycline MoA

A

Interferes with 30S ribosome protein production

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16
Q

Doxy can be used to treat what?

A

Syphilis
Gonorrhea (with ceftriaxone, 2nd to azithro)
CAP, sinusitis, Lyme, ricketssiae, rosacea, periodontitis, cholera

17
Q

Taking Doxycycline with what food interferes with absorption?

A

antacids/milk

18
Q

Tenofavir /Emtricitabine has what MoA

A

interferes with DNA polymerase function resolution gin viral inhibition

19
Q

Tenofavir/Emtricitabine is indicated for what?

A

HIV1 and pre-exposure prophylazix

Unlabed: Hep B

20
Q

Common s/e of Tenofavir/Emtricitabine

A

resistance

21
Q

Contraindications of Tenofavir/Emtricitabine

A

Adefovir, lamivudine

high risk of liver disease

22
Q

What is the black box warning for Tenofavir/Emtricitabine

A

lactic acidosis

23
Q

Valcyclovir has MoA of what?

A

Inhibits DNA polymerase

Incorporates into viral DNA

24
Q

Valcyclovir is indicated for what?

A

HSV

Herpes zoster

25
Q

What are common s/e of valcyclovir?

A 
NV
dizziness, abdominal pain
arthralgia
depression
fatigue
rash
26
Q

Clotrimazole cream has what MoA?

A

Alters fungal cell wall permeability

27
Q

What is clotrimazole cream used to treat?

A

Vulvovaginal or breast Candiasis

Fungal infections

28
Q

Can you use oral diflucan in pregnancy?

A

nope

29
Q

Nitrofurantoin has what MoA?

A

Inhibits several bacterial enzyme systems including acetyl coenzyme A interfering with metabolism and possibly cell wall synthesis

30
Q

What are the indications for use of nitrofurantoin?

A

UTIs due to e.coli, S. aureus, enterococcus, klebsiella, enterobacter

31
Q

What are common s/e of nitrofurantoin?

A

pulmonary infiltration and fibrosis

32
Q

Ibuprofen MoA

A

Analgesic and anti-pyretic effects through inhibition of prostaglandin synthesis

33
Q

Indications of Ibuprofen

A

Pain, fever, HA, dysmenorrhea, RA

34
Q

Common S/E of ibu

A 
CV thrombotic events
Stroke
MI
GI bleed
Elevated LFTs
35
Q

Contraindications for IBU

A

Pts for whom ASA/NSAIDs cause asthma, urticaria or allergic reactions

36
Q

Can you use ibu during pregnancy after 30 weeks gestation?

A

You shouldn’t - category D

Repro Flash Cards (2 decks)

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