PHARMACOLOGY Flashcards
1
Q
what is drug absorption?
A
drug is absorbed from the site of administration and enters into the plasma
2
Q
what is drug distribution?
A
drug reversibly leaves the bloodstream and is distributed into interstitial and intracellular fluids
3
Q
what is drug metabolism?
A
drug transformation by the liver and other tissues
4
Q
what is drug excretion?
A
drug and/or drug metabolites excreted in urine, faeces or bile
5
Q
why is solubility important for drugs?
A
lipid soluble drugs are more likely to diffuse lipid bilayer membranes
6
Q
what are the four ways in which small molecules can cross cell membranes?
A
passive diffusion
facilitated diffusion
active transport
endocytosis/pinocytosis
