Pharmacology

Question 1

Pharmacokinetics

Answer 1

Factors involved in getting the drug to its target

Absorption, distribution, biotransformation, excretion

Question 2

Pharmacodynamics

Answer 2

What the drug does at the target

Question 3

Simple diffusion

Answer 3

More lipid soluble, faster rate

Question 4

Absoprtion

Answer 4

Enters blood without modification, amount of active drug in circulation

Question 5

Distribution

Answer 5

Limited by rate of blood flow
Volume= amount administered/concentration of drug in plasma
Storage= adipose (primary), bone, mm, organs
Typical distribution start out high in blood > viscera > muscle > fat

Question 6

Biotransformation

Answer 6

Chemical change following administration
Aids excretion by creating a more polar, water soluble compound
Occurs in liver (primary), lung, kidney, GI, skin
Oxidation, reduction, hydrolysis, conjugation

Question 7

Excretion

Answer 7

Kidneys (primary), lungs, saliva, tears, sweat, GI
Clearance= ability to eliminate drugs
Determined by blood flow and excretion ratio

Question 8

Calcium channel blocker side effects

Answer 8

Dizziness, hypotension

Question 9

Vinchristine (cancer drug?) side effects

Answer 9

Foot drop

Question 10

Beta blockers side effects

Answer 10

Vital signs are NOT accurate

Use RPE

Question 11

Antihistamine (H1 vs H2 Blocker)

Answer 11

H1= respiratory
H2= GI