Pharmacology Flashcards
1
Q
What’re receptor is Aprepitant an antagonist of?
A
NK1
2
Q
When added to 5Ht3 and Dex, aprepitant improves N&V by how much?
A
20%
3
Q
Morphine half life prolonged in renal pts. This is explained by..
A
Impaired elimination of morphine 6 glucoronide
4
Q
What affects the steady state conc most of an orally bioavaialble drug?
A
Clearance
Steady state = (bioavailabilty x dose) ÷ (clearance x dosing interval)
5
Q
Morphine 3 glucoronide can lead to
A
Neurotoxcity - myoclonus, seizure
It’s a metabolite of morphine (M6G is the analgesic one)
6
Q
A
