Pharmacology Flashcards
Clinical features of MDMA
tachycardia and hypertension
agitation
low sodium
high temp
Which drug class can precipitate dig toxicity
Thiazides such as indapamide
What visual change might you see in dig toxicity
yellow green vision
Which drugs can cause dig toxicity
Thiazides
Amiodarone
Quinidine
Verapamil
Diltiazem
Spiro
MOA of cocaine
blocks uptake of dopamine, noradrenaline, serotonin
Nitrofurantoin is best avoided at what CKD level
3
Management of organophosphate poisining
Atropine
How do macrolides work
inhibit protein synthesis by blocking translocation
bacteriostaticW
which of the RIPE drugs affect p450 system
Rifampicin (rifAMPicin)
Isoniazid (inhibits)
MOA aspirin
None-reversible COX1 and 2 inhibitor
Monitoring of the following drugs
Statins
ACEi
Amiodarone
Statin: LFT 0, 3, 6 months
ACEi: UEs before, dose change, annually
Amiodarone: TFT LFT before (+UE CXR) and every 6 months
Sodium valproate monitoring
LFTs periodically through first 6 months
MOA metformin
increased insulin sensitivity
decreases hepatic gluconeogenesis
Side effects of sulfonIDEureas
hypos
weight gain
SIADH
liver dysfucntion
Side effects of glitazones
weight gain
fluid retention
liver
fractures
which diabetic drug class can cause pancreatitis
gliptins
Which electrolyte abnormalities can cause dig toxicity
low K
low Mg
high Na
High Ca
How does allopurinol work?
Inhibits xanthine oxidase
Memory aid for RIPE drugs
Rifampicin - red/orange
Isoniazid - ‘i’nhibits liver, ‘i’ns and needles
Pyrazinamide - ‘p’ainful joints
Ethambutol - ‘E’yes
Which anti seizure drug can auto-induce itself
Carbamazapine
Side effects of the following drugs
Amox
Fluclox
Co-amox
Erythro
Cipro
Metro
Doxy
Amox - rash with IM
Fluclox - cholestasis
Co-amox - cholestasis
Erythro - prolonged QT
Cipro - tendinitis
Metro - reaction with alcohol
Doxy - photosensitivity
In what situations should continuous HRT be given
- LMP > 1year ago
- Been on cyclical for more than 1 year
- LMP > 2 years in premenopausal women
Drug of choice for nausea related migraine
Metoclopramide
which ppi should not be prescribed if taking clopidogrel
omeprazole
esomeprazole
What should be monitored in haemochromatosis treatment?
transfern saturation
serum ferritin
TIBC is high in haemochromatosis
false. low
risk factors for SCC of the oesophagus
smoking
alcohol
achalasia
Risk factors for adenocarcinoma of the oesophagus
GORD
Barrett
smoking
fat
Which situations is TIBC raised
IDA
pregnancy
oestrogen
Formula for units in a volume
ABV X volume / 1000
Antibodies seen in Primary Biliary Cirrhosis
AMA
Which drug can help with pruritus in PBC
cholestyramine
deranged liver function and amenorrhea
autoimmune hep
indications for spiro use
ascites
hypertension: used in some patients as a NICE ‘step 4’ treatment
heart failure
nephrotic syndrome
Conn’s syndrome
these drugs should be avoided with SSRIs
titans
aspirin
MAOIs
warfarin and heparin
which SSRI are associated with long qt
citalopram
Antidepressant often used in the elderly
Mirtazapine
Effect of quinolones on seizure threshold
Lowers threshold
Patients allergic to aspirin may also react to this anti rhemumatic drug
Sulfasalazine
