Pemphigus Vulgaris Flashcards
1
Q
What is pemphigus vulgaris?
A
An autoimmune disease caused by antibodies against desmoglein 3, a cadherin-type epithelial cell adhesion molecule.
2
Q
What population is pemphigus vulgaris found in?
A
Ashkenazi Jewish
3
Q
What are the features of pemphigus vulgaris?
A
Mucosal ulceration (50-70% oral involvement)
Skin blistering - flaccid, easily ruptures vesicles and bullae. Painful but not itchy.
Acantholysis on biopsy
4
Q
What is the management o pemphigus vulgaris?
A
Steroids are first-line
Immunosuppressants
