PARKINSON DISEASE

Question 1

how does Parkinsonism present?

Answer 1

any combination of bradykinesia, rest tremor, rigidity, or postural instability.

Question 2

etiology of parkinsonism?

Answer 2

genetic mutation
environmental exposure (toxins, CO)
reversible/drug-induced
lesion
idiopathic(most common) =Parkinson’s disease

Question 3

what is the pathogenesis of Parkinson’s disease?

Answer 3

degeneration of dopaminergic nigrostriatal system. results in dopamine depletion in corpus striatum; affects direct and indirect pathway.