Oncology

Question 1

Risk of malignant transformation of osteochondroma in MHE?

Answer 1

5%

Question 2

Risk of malignant transformation of enchondroma in Olliers and Maffuci Syndrome?

Answer 2

25% for Ollier
100% for Maffuci

Question 3

What is the most common benign bony tumor of the hands and feet?

Answer 3

Enchondroma
(IDH1 and IDH2 mutation)

Question 4

Gene involved and mode of inheritance for MHE?

Answer 4

EXT1,2 (Heparn sulfate synthesis)
Autosomal Dominant with Incomplete Penetrance

Question 5

What is a rare, benign lesion classically located in the epiphysis of skeletally immature individuals?

Answer 5

Chondroblastoma

Question 6

For osteochondroma, a cartilage cap greater than how many cm or a growing cartilage cap is concerning for malignant transformation in adults?

Answer 6

2 cm

Question 7

What is the most common site for osteoid osteoma?

Answer 7

Proximal femur

Question 8

Rearrangment of what genes are associated with osteoid osteoma and osteoblastoma?

Answer 8

FOS and FOSB

Question 9

What makes something a II instead of I in the AJC cancer staging?

Answer 9

High grade and then A or B if < or > 8 cm

Question 10

What are the toxicities of cisplatin?

Answer 10

Audiotoxic, Nephorotoxic, neurotoxic

Question 11

What sarcomas is chemotherapy used for?

Answer 11

Rhabdoyosarcoma and synovial sarcom

Question 12

What size should worry me with a soft tissue mass?

Answer 12

Greater than 5 cm

Question 13

What sarcomas metastasize to the lymph nodes?

Answer 13

ESARC: Epithleiod, synovial sarcoma, angiosarcoma, rhabdomyosarcoma, clear cell sarcoma

Question 14

What stains positive for myogenin and MyoD1?

Answer 14

Rhabdomyosarcoma

Question 15

What is the most common sarcoma in the foot?

Answer 15

Synovial sarcoma

Question 16

What is positive for keratin and EMA?

Answer 16

Synovial Sarcoma

Question 17

What is the most common sarcoma of the hand?

Answer 17

Epitheloid