Obstetrics Flashcards
where is the symphyseal- fundal height measured from?
measured from the top of the uterus to the pubic symphysis
correlates to gestational age +/- 2cm
what is a breech presentation?
the baby’s sacrum is in the pelvis, rather than the baby’s head
where does fertilisation occur?
the ampulla of uterine tubes
once the ovum is fertilised a blastocyst is formed. what is a blastocyst ?
the term used to describe when embryo has divided into 2 separate cells
the inner cell develops embryo
outer cell becomes the trophoblast and goes on to develop placenta
what 2 hormones are secreted by the placenta?
HCG
Progesterone
what is the role of HCG?
stimulates corpus lutem to produce progesterone
this prevents endometrial shedding and ensures early nutrition of embryo
when do levels of HCG peak?
they continue to increase up until week 10, when they peak and then subsequently reduce
name the 2 main functions of progesterone?
- prepares and maintains endometrium
2. reduces uterine contractions
how do progesterone levels change throughout pregnancy?
they continue to increase steadily throughout pregnancy
where is progesterone produced?
initially produced by the corpus luteum
then produced by the placenta
name the 3 actions of oestrogen?
- development of breasts
- enlargement of uterus
- relaxation of pelvic ligaments
what happens to maternal PCO2 during pregnancy?
it is reduced
what happens to maternal Hb during pregnancy? why does this happen?
Hb levels reduced
a result of the increased plasma volume causing haemo-dilution
during labour, which 3 hormones are responsible for increasing uterine contractions?
oestrogen
oxytocin
prostaglandins
which hormone during labour stimulates prostaglandin release?
oxytocin
what is Ferguson reflex, which is seen in labour?
stretching of the cervix stimulates oxytocin release
oxytocin release results in further stretching of the cervix and activation of the reflex
how can ‘false’ contractions, known as Braxton hicks be resolved?
unlike ‘true’ contractions, they can be resolved by lying down or changing position
what is a normal number of contractions at peak during labour?
3 or 4 contractions every 10 minutes
how prolonged does a pregnancy have to be for it to be induced?
> 41 weeks
what is usually given 1st line to induce labour?
topical prostaglandin to the cervix
describe the definitions of the 3 stages of labour?
stage 1: onset of labour to full dilatation of cervix (within this, there is a latent and active stage)
stage 2: full dilatation to delivery
stage 3: delivery of baby to the delivery of placenta and membranes
compare the maximal acceptable time for a nulliparous women with and without anaesthesia to be in stage 2 of labour
nulli w/ anaesthesia: 3 hours
nulli w/o: 2 hours
compare the maximal acceptable time for a multiparous women with and without anaesthesia to be in stage 2 of labour
multi w/ anaesthesia: 2 hours
multi w/o anaesthesia: 1 hour
why is active management of stage 3 labour preferred to expectant management?
active mamagement reduces risk of PPH
what is classed as failure to progress in labour?
less than 2cm in 4 hours
how does the onset and duration of a spinal compare to an epidural?
spinals have a faster onset of action and dont last as long
what type of anaesthetic is preferred for C sections
spinal anaesthetic
what is the most common cause of puerperal pyrexia ?
what should be done if this is found ?
most common cause = endometritis
admit for IV clindamycin and gentamicin until px afebrile for 24 hours
what is the main risk associated with external cephalic version?
Rh autoimmunisation
what does fetal distress indicate?
fetal hypoxia
what is muconeum stain liquor? what is this a sign of?
it is when the liquor is thick and green due to baby passing bowel movements
a sign of fetal distress or post term baby
what is terbutaline and when can it be used?
it is a tocolytic (anti-contraction)
can be used in cases of fetal distress to stop contractions and allow for an operative delivery
when do the majority of cord prolapses occur?
during artificial rupture of membranes
describe the presentation of a cord prolapse
fetal distress seen following rupture of membranes
pulsatile mass seen on vaginal exam
how is a cord prolapse managed
continual CTG
push presenting part of fetus back into uterus to reduce compression
give terbutaline and prepare for cat 1/2 CS
what technique can be used in cases of shoulder dystocia?
McRobert’s position
woman lies flat with thighs against abdomen
name the nerve roots affected in the 2 nerve palsies that may occur in shoulder dystocia
- Erb’s palsy: C5,6, 7
- Klumpkes palsy: C8-T1
what happens when amniotic fluid enters the maternal circulation?
- cardiopulmonary compromise
- severe DIC
in which patients is a uterine rupture most likely to occur?
patients who are having a vaginal birth after a caesarean
how does a uterine rupture present?
loss of engagement
fetal distress
maternal shock
how is a uterine rupture managed?
emergency laparotomy
which landmarks is an episiotomy made from?
the vagina to the ischio-anal fossa
what gestational dates define preterm labour?
delivery from 37 - 42+0 weeks
what are the gestational dates associated with the following pre term labours?
1) moderate/late
2) very
3) extremely
1) moderate/late: 32-37 weeks
2) very: 28-32 weeks
3) extremely <28 weeks
what antibiotic is given to mothers who have a preterm pre labour rupture of membranes?
erythromycin
what is the role of dexamethasone in premature babies?
helps to promote maturity of the lungs by stimulating surfactant production
when is magnesium sulphate given and why is it given?
given in established labour
it provides baby with neuroprotection
what options is there to delay a preterm labour?
pharmacological: nifedipine
surgical: Mcdonald’s suture (pinches the cervix shut)
what is the definition of placental retention in active or passive management of stage 3?
active management: >30 mins
passive management: > 60 mins
what happens in placenta accreta?
the placenta embeds in the myometrium due to defective decidua basalis (bottom layer of placenta)
in addition to a CS, what should also be planned following delivery for the mother? why?
hysterectomy
post delivery contraception
this reduces risk of PPH
why is uterine inversion considered an emergency?
high risk of maternal shock and PPH
describe uterine inversion?
when the uterine fundus collapses into the endometrial cavity
staging is dependant on just how inverted the uterus is
in uterine inversion, following manual replacement of the uterus, what is given? why is this given?
oxytocin is given
it maintains uterine contractions to prevent another inversion
what amount of blood loss constitutes PPH?
> 500mls of blood loss following delivery
what timescale does a secondary PPH occur in?
24hours- 12 weeks following delivery
name the 4 T’s that can cause PPH?
Tone - uterine atony
Trauma- perineal damage
Tissue- retained placenta (placenta accreta)
Thrombin - DIC
which cause of PPH would present with an extremely painful uterus on palpation and vaginal bleeding?
uterine rupture
what is the most common cause of PPH?
uterine atony
how is uterine atony managed?
oxytocin administered
controlled cord traction
cord clamping between 1-5 minutes
in the medical management of uterine atony/PPH, who should not be given IV syntocinon (oxytocin)
those with hypertension
at what point is a downs screening, including nuchal thickness testing done?
11 - 13+6 weeks
if a pregnant woman is found to be rhesus -ive, when is the 1st dose of anti D given?
28 weeks
when is folic acid given and why is it given?
should be taken 3 months preconception and for the duration of the 1st trimester
to reduce neural tube defects
which vitamin is tetatogenic and should be avoided in pregnancy?
vitamin A
describe how HCG, inhibin A, AFP, PAPA and estriol are affected in downs?
High: HCG and inhibin A
Low: AFP, PAPA and estriol
how is AFP affected in cases of twins?
AFP is raised
which common genetic condition also causes cardiac abnormalities?
downs syndrome
can cause ASD, PDA, tetralogy of fallot
which genetic condition presents with cardiac, GI and urogenital abnormalities + severe mental disability?
what is the genetic change?
Edward’s syndrome
trisomy 18
which genetic condition presents with cleft palate, microcephaly and severe mental disability?
what is the mutation seen?
Patu syndrome
trisomy 13
compare when chorionic villus sampling can be carried out compared with amniocentesis?
chorionic villus sampling: 10-13 weeks
amniocentesis: >15 weeks
CVS therefore allows chromosomal abnormalities to be identified earlier
name 5 of the risks of chorionic villus sampling and amniocentesis
- infection
- bleeding
- Rh autoimmunisation
- misscarraige (higher in CVS)
- amniotic fluid leak
name 2 advantages of amniocentesis over CVS?
- allows neural tube defects to be identified
- it is safer (miscarriage rate is 1% for amniocentesis and 2% for CVS)
compare what is sampled in chorionic villus sampling v amniocentesis
CVS: the placenta
amniocentesis: amniotic fluid
compare FISH and array CGH in terms of what they test for genetically?
FISH: targeted
array CHG: tests whole genome
what would an asymmetrical growth restriction suggest as the cause of growth restriction?
placental insufficiency
the head circumference is normal but abdominal circumference low
suggests the restriction occurred later in pregnancy, making placental insufficiency likely
how much larger than expected does the symphyseal-fundal height have to be to diagnose large for dates?
SF height > 2cm than expected for dates
what is the commonest type of monozygotic twins?
monochorionic, diamniotic