NSAIDs Flashcards
At what week of pregnancy is NSAID C/I?
A. 20 WEEKS
B. 28 WEEKS
C. 15 WEEKS
D. 4 WEEKS
(B) due to increased risk of premature closure of the ductus arteriosus (essential for perfusion of foetus in absence of functioning lungs), fetal renal dysfunction, prolongation of maternal bleeding time and inhibition of uterine contraction during labour.
In what situation should NSAIDs use in women be monitored?
When they are at week 20 (first and second trimester) and the use of NSAID is still indicated they require antenatal monitoring for oligohydramnios due to risk of that occurring whilst on NSAID.
[The blockade of prostaglandin synthesis by NSAIDs and decreased activation of prostaglandin receptors reduce renal perfusion THUS reducing fetal urine production, which is the main source of amniotic fluid, particularly from second trimester onwards. This explains why NSAID is not ADVISED past 20 weeks and if there are suspected signs of oligohydramnios in mothers it should be STOPPED. ]
Which risk factor in elderly would required NSAID to be stopped?
A. eGFR <50 mL/min
B. Gout where the C/I Xanthine oxidase inhibitor
C. Dental pain that can be managed with paracetamol
D. eGFR <60 mL/min
A
Which NSAIDs from this list exhibits the highest risk associated with GI S/E?
A. Ibuprofen
B. Piroxicam
C. Naproxen
D. Indomethacin
H. Ketorolac
I. Ketoprofen
(B) H I
Which NSAIDs from this list exhibits intermediate risk associated with GI S/E?
A. Ibuprofen
B. Piroxicam
C. Naproxen
D. Indomethacin
(c) and D also diclofenac
Which NSAID, at said dose, has increased risk of thrombotic event ?
A. Diclofenac 150mg daily
B. Ibuprofen 1.2g daily
C. Naproxen 1g
D. Ibuprofen 2.4 g daily
(A) and (D)
Which NSAID, at said dose, has low risk of thrombotic event?
A. Diclofenac 150mg daily
B. Ibuprofen 1.2g daily
C. Naproxen 1g
D. Ibuprofen 2.4 g daily
© and (D)
Which NSAID is indicated to the use in migraine?
A. Tolfenamic acid
B. Ketorolac trometamol
C. Piroxicam
D. Tenoxicam
E. Meloxicam
F.Mefanamic acid
(A)
Which NSAID is a ONCE a day preparation?
A. Tolfenamic acid
B. Ketorolac trometamol
C. Piroxicam
D. Tenoxicam
E. Meloxicam
F.Mefanamic acid
G. Parecoxib
H. Celecoxib
(D) and (C)
Which NSAID is used for management of osteoarthritis
A. Tolfenamic acid
B. Ketorolac trometamol
C. Piroxicam
D. Tenoxicam
E. Meloxicam
F.Mefanamic acid
G. Parecoxib
H. Celecoxib
H (and etoricoxib)
Which NSAID is associated with diarrhoea and haemolytic anaemia?
A. Tolfenamic acid
B. Ketorolac trometamol
C. Piroxicam
D. Tenoxicam
E. Meloxicam
F. Mefanamic acid
G. Parecoxib
H. Celecoxib
F Immune complex mechanism similar to methyldopa and aspirin
Which NSAID is superior to naproxen but with high incidence of side effects including headaches, dizziness and GI disturbances?
A. Tolfenamic acid
B. Ketorolac trometamol
C. Piroxicam
D. Tenoxicam
E. Meloxicam
F. Mefanamic acid
G. Indometacin
H. Celecoxib
G
Which NSAID is an active enantiomer of ibuprofen?
A. Tolfenamic acid
B. Ketorolac trometamol
C. Piroxicam
D. Tenoxicam
E. Meloxicam
F. Mefanamic acid
G. Indometacin
H. dexibiburfen
(H)
