Non-Competitive inhibitors

Question 1

What are Non-Competitive Inhibitors?

Answer 1

• They do not have a similar shape to the substrate
• these molecules attach to the enzyme but not the active site
• they bind to a different site on an enzyme molecule - ALLOSTERIC
• distorts the shape of the enzyme as a whole, so changes the shape of the active site
• substrate molecule can no longer fit into the active site
• reaction rate slows down

Question 2

FEATURES of non-competitive inhibitors?

Answer 2

• IRREVERSIBLE
• highly toxic, useful

Question 3

What are ORGANPHSOPHATES?

Answer 3

• used in INSECTICIDES - to kill insects
• they permamently join to the enzyme needed for nerve iimpulse transmission, preventing normal never impulses, reducing the paralysis and death.

Question 4

What are PROTON PUMP INHIBITORS (PPIs)?

Answer 4

• Used to treat indigestion in humans
• They permanently block the action of an enzyme needed to make stomach acid, so less acid is made,
• helps prevent stomach ulcers.