Neurotransmission & Drugs

Question 1

Name the TCAs. 4

Answer 1

Amitryptyline
Imipramine
Nortriptyline
Lofepramine

Question 2

Name MAOIs 4

Answer 2

Phenelzine
Tranylcypromine
Isocarboxazid
Moclobemide - reversible

Question 3

Name SSRIs 5

Answer 3

Citalopram
Escitalopram
Fluoxetine
Paroxetine
Sertraline

Question 4

Name SNRIs 2

Answer 4

Venlafaxine

Duloxetine

Question 5

Interactions of SSRIs -3

Answer 5

MAOIs, alcohol, NSAIDs

Question 6

TCA interactions?-2

Answer 6

Other sedative drugs

QT prolongation drugs

Question 7

MAOI interactions? -3

Answer 7

Tyramine rich food
Opioids
Antidepressants

Question 8

Glutamate?-3

Answer 8

Excitatory NT
Ionotropic & metabotropic
Main exc. NT in CNS

Question 9

Monosodium glutamate -2

Answer 9

Activates glutamate receptors on tongue

Umami flavour

Question 10

GABA? -3

Answer 10

Gamma-aminobutyric acid
Main INHIBITORY NT of CNS
Ionotropic & metabotropic

Question 11

Which GABAs are iono or metabo?

Answer 11

GABA-a is ionotropic

GABA-b is metabotropic

Question 12

Activation of GABA?

Answer 12

Sedation (BENZODIAZEPENES)

Question 13

Glycine? -3

Answer 13

Other major inhibitory NT (other = GABA)
Ionotropic
Mostly active in brainstem and spinal cord

Question 14

Serotonin 4

Answer 14

DO loads of things!
Stores in enterochromaffin cells
Involved in peristalsis
Serotonin hypothesis for depression

Question 15

Acetylcholine 5

Answer 15

Synth in all motor neurones of spinal cord and brainstem
Main NT of autonomic nervous system
NMJ
Muscarinic receptors - metabotropic 
Nicotinic receptors - ionotropic

Question 16

Dopamine 3

Answer 16

Metabotropic receptors
Reward-motivated behaviour
Many effects peripherally