Neuron death, neuron growth and neurotrophins Flashcards
match neurotrophin to receptor NGF BDNF NT-3 NT-4
NGF- TRK A
BDNF-TRK B
NT-3-TRK C
NT-4-TRK B
Model for neurotrophic hypothesis
chich embrto, limb bud,cells in DRG innervating limbs
remove limb bud=fewer motor nand DRG neurons
conc: target influences neuron survival
Neurotrophin hypothesis by Hamburger and MJ
Neurons send axons to peripheral targets. The cells synthesize factors, there’s a limiting amount of target derived factor, amount of factor produced is propotional to the cells in the tissue
Model fro discovery of NGF
Cohen and Levi Montalani
mouse limb, cells in the DRG and sympathetic ganglia larger than to side where they weren’t detected
p75 binds to all neurotrophic factors
true
2 receptors with death domain to signal death
p75
FADD
During axonal growth, which neurotrophic factor do cells express
NT3, TRK C receptor
when neurons mature after axonal growth, which neurotrophin do they express to move from periphery to cell body
NGF-TRKA
Example of antiapoptotic regulator and proapoptotic
BCL2-anti
BAX-pro
Neurotrophins eg NGF prevent cells from dying. True/false
True
2 types of neurons in the DRG
Nociceptors
Mechanoreceptors
define birth of nociceptors and mechanoreceptors
low threshold Trk B- early born- mechanoreceptors, large cells, lower proliferation
high threshold Trk A- born later-nociceptors-large and small- inc proliferation
low threshold Trk C- proprioceptors
BDNF is greater than NT3 and NGNF in synaptic plasticity. TRue/false
true
Define hyperaglesia
Increased sensitivity to a normally mild symptom eg heat aglesia. NGF TRKA modulated. NGF produces sensitization by increasing production of BDNF
above 45 degrees celcius stimulation of sensory neurons activates which neuromodulator
NGF, TRK A and TRPV1
