Neurology - MS Flashcards
1
Q
What is the pathology of MS?
A
autoimmune demyelination
Immune response mediated by T cells lead to inflammatory attack with demyelination of white matter of spinal cord
2
Q
What are the signs of MS?
A
pain, sensation problems, optic neuritis, weakness (irregular), how shower worsens symptoms
3
Q
How would you test for MS?
A
CT/MRI, LP (oligocordial bands), NCS
4
Q
How would you treat MS?
A
steroids, DMARDs (IFN-B prevents immune activation, natalizumab modifies lymphocyte trafficking)
stem cell transplant
5
Q
What is the treatment for MS?
A
steroids in relapse DMARDs - interferon monoclonal antibodies - alemtuzumab, natalizumab tecfidera - dimethyl fumerate stem cell transplant
6
Q
Name 3 patient speak phrases of MS
A
got worse in the shower tripping blurred vision blurred vision electric shock feeling down spine
7
Q
What is the criteria to diagnose MS?
A
2 or more CNS lesions disseminated in time and space
- exclude other conditions
