What is a Paramecia?
A single celled eukaryote, that does not require neurons for complex movements.
What do Paramecia use to move?
Cilia and ion channels.
What indicates that ion channels and electrical gradients developed very early on in evolution?
Prokaryotes have precursor ion channels of a more complex nervous system.
Why do large multicellular organisms require direct connections between sensory and motor cells?
Because diffusion of chemical transmitters would be too slow and it is difficult to produce specific responses from this.