nephrotic/nephritic

Question 1

prototype of nephrotic syndrome

• kids
• PCT
• Light micro=normal
• Electron micro=fused foot
• steroids work well

Answer 1

minimum change dz

Question 2

• resistant to steroid therapy

- focal changes/segmental changes

Answer 2

focal segmental glomerulosclerosis

Question 3

• Immune complex deposition
• light micro=thickened capillary loops
• electron micro=BM thick
• Spike and dome appearance
• granular immunofluorescence
• steroids don’t really work

Answer 3

Membranous glomerulonephritis

Question 4

• Electron micro=increased gbm thickness
• inc mesangial matrix
• kimmel steil nodules
• thickened afferent and efferent arterials
• capsular drop on bowmans capsule
• fibrin cap on visceral portion
• armanni-ebstein lesion

Answer 4

diabetic nephropathy

Question 5

• Identified with congo red
• electron micro=crisscross pattern
• a/w Rheumatoid, plasma cell disorders, multiple myeloma

Answer 5

amyloidosis

Question 6

• mesangial proliferation
• endothelial proliferation
• inflammatory reaction
• extensive scarring
• small focal thrombosis
• subendothelial immune complex deposition
• wire loop abnormality
• fingerprint pattern of immune complexes

Answer 6

SLE

Question 7

• Prototype of nephritic
• a/w strep
• follows infection with group A beta-hemolytic strep
• immune complex dz
• bilateral
• petechial hemorrhages cover surface of kidney
• electron dense humps
• azotemia
• INCREASE ASO

Answer 7

acute proliferative glomerulonephritis

Question 8

• crescent formation from proliferation of parietal epithelial cells of bowman’s capsule
• rapid dev of renal failure
• anti glom bm antibodies a/w good pastures
• linear immunofluorescence

Answer 8

rapidly progressive glomerulonephritis

Question 9

• antiglomerular bm antibodies
• antibodies directed against antigens in glomerular and pulmonary alveolar bm
• pneumonitis with hemoptysis
• linear immunofluorescence

Answer 9

goodpasture syndrome

Question 10

• a/w nerve deafness and ocular disorders
• irregular bm thickening with foci of splitting of lamina densa
• mutation in gene for alpha-5 chain of type 4 collagen

Answer 10

alport syndrome

Question 11

• mesangial igA deposition
• follows infection and lasts 1-2 days
• a/w henoch-schonlein purpura

Answer 11

berger dz

Question 12

• bm thickening and cellular proliferation
• reduplication of BM into 2 layers–>tram track appearance
• type 1=immune complex nephritis
• type 2=dense deposit dz

Answer 12

membranoproliferative glomerulonephritis

Question 13

• renal failure with reduced glomerular and tubular function
• HTN almost always present
• kidneys are small and pale
• glom are scarred and hyalinzed
• hyaline arteriolosclerosis
• interstitial fibrosis

Answer 13

chronic glomerulonephritis/end stage kidney