Nanomedicine

Question 1

What is a nano particle

Answer 1

Solid polymeric particle

Question 2

Size of nanoparticles?

Answer 2

10 -9 nm

Question 3

Nanoparticles vs standard chemotherapy

Answer 3

Nanoparticles
• better target specificity
• specific drug delivery, less systematic distribution
• few ADR
• less drug resistant (as it can modify drug delivery system)
• better tissue permeation - esp in solid tumours
•longer circulation time - less frequent dosing
• expensive in price

Chemotherapy
• non targeted deliver (affecting healthy cells)
• systematic distribution
• more ADR (hair loss, nausea immune suppression)
• drug reistance (as cancer cells can develop mechanisms - efflux pumps, change in target site)
• poor tissue penetration esp in solid tumours
• shorter circulation time - more frequent dosing
• cheaper in price

Question 4

How can nanoparticles be used as imaging enhancers

Answer 4

Coated with imagining agents, they can show exactly where tumours are

Question 5

What is their part in phototherapy therapy

Answer 5

Gold nanoparticles can covert light into heat, so we only target the cancer cells only

Question 6

Can they be loaded with chemo agents

Answer 6

Yes - loaded with chemo agents, they can be controlled released at target site

Question 7

Why do we need nano medicine

Answer 7

• avoid first pass metabolism
• avoid quick clearance
• better drug penetration
• avoid non specific drug distribution