Myelodysplastic syndromes Flashcards
1
Q
myelodysplastic syndrome description
A
pre-leukemia primary neoplastic stem cell disorders clonal in orgin 1+ cytopenias ab. maturation in bm (dysplasia)
2
Q
FAB of myelodysplastic syndromes
A
based on: % bm blasts (<30%) % peripheral blood blasts presence of ringed sideroblasts % of monocytes extent of cytopenia degree of dysplasia
3
Q
myelodysplastic syndromes etiology
A
idiopathic oncogenes 2* to chemo/radiation environmental chromo ab. (Down's synd) loss of tumor suppressor gene
4
Q
myelodysplastic syndromes clinical course
A
adult >50yoa
may transform to acute leukemia
fatigue, infec.
5
Q
myelodysplastic syndromes laboratory presentation
A
anemia neutropenia \+/= thrombocytopenia dysplasia in 1+ lines macrocytes, dimorphic pop., anisocytosis, basophilic stippling, Howell-Jolley bodies
6
Q
myelodysplastic syndromes differential characteristics
A
\+/= left shift wbc morph abnormalities pelger huet hypogranular wbc fx abnormalities increased monocytes
7
Q
myelodysplastic syndromes bm characteristics
A
erythroid hyperplasia
megaloblastoid
ringed sideroblasts
8
Q
myelodysplastic syndromes serum testing characteristics
A
increaced/normal Fe normal/decreased TIBC normal B12/folate chromo abnormalities decreased Tcells
9
Q
myelodysplastic syndromes therapy
A
survival <2yrs mortality rate 58-72% death due to infection convert to acute leukemia 10-40% transfusion/antibiotics/chemo/cytosine arabinoside/ bm transplant
