MSK pg 429-433 first aid 2015

Question 1

MCP spared

a. osteoarthris
b. RA

Answer 1

osteoarthritis

Question 2

RA which joint spared

Answer 2

DIP

Question 3

pain improved with rest OA or RA

Answer 3

OA

Question 4

TNF alpha inhibitors for RA

List 3

Answer 4

etanercept (Enbrel), adalimumab (Humira), infliximab (Remicade), and certolizumab pegol (Cimzia)

Question 5

what type of glucocorticoids would you give to osteoarthritis?

Answer 5

intra-articular

Question 6

list two DMARDS for RA

Answer 6

Methotrexate

Sulfasalzine

Question 7

RA association which HLA

Answer 7

HLA-DR4

Question 8

what type of hypersensitivity is RA

Answer 8

Type III and IV

Question 9

Heberden nodes in OA

Answer 9

He dips

DIP

Question 10

Bouchard nodes in OA

Answer 10

Baby pip

PIP

Question 11

Pathology of rheumatoid nodules

Answer 11

fibrinoid necrosis

Question 12

Specific marker for RA

Answer 12

anti-cyclic citrullinated peptide antibody

Question 13

what is RF

Answer 13

IgM antibody against Fc portion of IgG

Question 14

antibodies of sjogren

Answer 14

SSA, SSB

Question 15

what are SS-A and SS-B

Answer 15

ribonucleoproteins

Question 16

Patient with Sjogren suddenly have unilateral enlargement of parotid gland

Answer 16

B cell lymphoma (MALT lymphoma)

Question 17

Patient with acute onset monoarthritis, episodic pain

Answer 17

gout

Question 18

what crystals

1. gout
2. pseudogout

Answer 18

gout: monosodium urate
pseudogout: calcium pyrophoshate (rhomboid)

Question 19

what type of joints do pseudogout affect

Answer 19

large joint

knee

Question 20

what type of diuretics can cause gout

Answer 20

Thiazide
HyperGLUC
hyperGlycemia,
hyperLipidemia, hyperUricemia,
hyperCalcemia.

Question 21

glycogen storage disease that cause gout

Answer 21

von gierke

Question 22

negative birefringent what color

Answer 22

yellow parallel (BLUE parallel in pseudo)
blue perpendicular

Question 23

diseases associated with pseudogout

Answer 23

hemachromatosis
hyperparathyroid
osteoarthristis

Question 24

infectious arthrtis in sexually active

Answer 24

N. gonorrhoeae

Question 25

IA in older kids and adults

Answer 25

S. aureus

Question 26

Gonococal arthrtis presentation

Answer 26

``` migratory arthritis with asymmetric pattern STD synovitis tenosynovitis dermatitis ```

Question 27

Seronegative spondyloarthropathies what HLA

Answer 27

HLA-B27 (MHCI)

Question 28

sausage fingers | pencil in a cup

Answer 28

psoriatic arthritis

Question 29

Bamboo spine

Answer 29

ankylosing spondylitis

Question 30

see Aortic Regurg in which type of Seronegative arthritis

Answer 30

Ankylosing spondylitis

Question 31

Can't see, can't pee, can't bend my knee

Answer 31

Reactive arthritis reiter

Question 32

cause of reactive arthritis

Answer 32

Post GI: shigella, salmonella, Yersinia, Campylo | Chlymadia

Question 33

Circinate balanitis

Answer 33

annular dermatitis of glan penis | seen in reiter

Question 34

keratoderma blennorrhagicum

Answer 34

hyperkeratotic vesicles in palms and soles | reiter

Question 35

SLE die with what type of kidney disease

Answer 35

nephritic DPGN

Question 36

most sensitive SLE

Answer 36

ANA

Question 37

most specific

Answer 37

dsDNA, anti-smith

Question 38

what is anti-Smith antibodies

Answer 38

Anti-snRNPs for splicing

Question 39

drug induced SLE what antibodies

Answer 39

anti-histone

Question 40

cause of drug-induced SLE

Answer 40

Hydralazine procanamide INH

Question 41

SLE patient given hydroxychloroquine. what do you have to monitor

Answer 41

retinal exam

Question 42

antibodies in antiphospholipid syndrome

Answer 42

lupus anticog anticardiolipin anti-B2 glycoprotein

Question 43

false positive VDRL

Answer 43

``` Viral infection (eg, EBV, hepatitis) Drugs (IV) Rheumatic fever Lupus and leprosy. Pregnancy ```

Question 44

lupus anticog produce paradoxical prolongation of PT or aPTT

Answer 44

PTT

Question 45

List the joint findings in osteoarthritis (6)

Answer 45

1. Osteophytes (bone spurs) 2. joint space narrowing 3. subchondral sclerosis and cysts 4. eburnation (polished ivory like appearance of bone) 5. Heberden nodes 6. Bouchard nodes Synovial fluid non-inflammatory (WBC

Question 46

this marker in SLE indicate poor prognosis

Answer 46

anti-dsDNA