Msk Patnologies (osteoarthiritis)

Question 1

What’s hip osteoarthritis

Answer 1

Loss of joint space, ostéophyte formation, subchondral sclerosis, subchondral cysts, deformity

Question 2

What’s articular cartilage

Answer 2

Structure and composition of normal cartilage and subchondral bone shows histology, cartilage composed of extra cellular matrix produced by Chondrocytes, extra cellular matrix = 80% water, collagen fibres, proteogylcans, glycosaminoglycams,and non collagenous chondrocytes

Question 3

What are the bony changes in OA (Kell gren Lawrence classification)

Answer 3

0= normal
1= doubtful, narrowing of joint space, possible ostéophyte development
2- definite ostéophytes, questionable narrowing of joint space
3- moderate narrowing, sclerosis, joint deformity
4- large ostéophytes marked narrowing, severe sclerosis

Question 4

What’s subchondral bone

Answer 4

Osteoclasts initiate bone matrix réabsorption osteoblasts then invade matrix leading to new bone formation , osteoclasts release enzymes which are responsible for breakdown of bone matrix