MSI /fMRI/ sEEG

Question 1

This FMRI is done during verb generation task vs resting. What does it show?

Answer 1

Broca’s area in left frontal lobe (note that positive right hemisphere findings are not atypical)

Question 2

What do each of the following correlate in terms of seizure localization
- Anterior temporal horizontal anterior-posterior dipole
- anterior temporal vertical dipole (2)
- posterior vertical dipoles

Answer 2

Anterior temporal horizontal anterior-posterior dipole
- mesial temporal seizure onset (ipsilateral)
Anterior temporal vertical dipole
- anterior temporal onset
- possible medial temporal onset
Posterior vertical dipoles
- lateral or nonlocalized seizure onset.

Question 3

In patients with MTLE, what do the following MSI findings indicate?
- ATV dipole
- ATH dipole (2)

Answer 3

ATV dipole: epileptic activity in medial basal temporal region (ipsilateral)
ATH dipole:
- temporal pole and adjacent part of lateral temporal cortex
- 50% with TH dipoles exhibit bitemporal spikes and/or seizure onsets

Question 4

sEEG in Mesial temporal lobe epilepsy:
what does a 1-2 Hz period spike-pattern at seizure onset suggest

Answer 4

(exclusively in hippocampus), correpastes with CA1 cell loss