mood stabilisers

Question 1

what are mood stabilisers used for

Answer 1

maintain frequency of manic behaviours, mood swings and aggressive behaviours

Question 2

examples of mood stabilisers

Answer 2

• lithium carbonate
• carbamezepine
• sodium valporate

Question 3

whats the MOA of lithium carbonate

Answer 3

blocks the serotogenic neurotransmission

Question 4

whats the MOA of carbamazepine

Answer 4

calms neuron by blocking the nero-sodium channels

Question 5

whats the MOA of sodium valporate

Answer 5

enhances serotogenic and reduce dopaminergic actions

Question 6

what are the side effects of lithium carbonate

Answer 6

• neurologic: slurred speech, hand tremors
• GI: nausea, polyuria
• endocrine: risk of hypothyroidism
• cardio: ecg changes

Question 7

what is the acceptable level of lithium carbonate

Answer 7

0.8-1.2 mEq/L

Question 8

what happens if the level of lithium goes above 1.5mEq/L

Answer 8

muscle weakness, diarrhoea, tremors, blurred vision

Question 9

what happens if the level of lithium goes above 2mEq/L

Answer 9

life threatening!
neurotoxicity, delirium and encephalopathy

Question 10

what are side effects of carbamazepine

Answer 10

neurological: headache, sedation, confusion
GI: nausea, constipation
!!!! stevens johnson syndrome !!!!!

Question 11

what are side effects of sodium valporate

Answer 11

neurological: headache, sedation, confusion
GI: nausea, constipation