Monosaccharide Metabolism Flashcards
Glycolysis yields
2 pyruvate and a net gain of 2 ATP and 2 NADH
control points of glycolysis
phosphofructokinase 1 (PFK-1)
pyruvate kinase
ANAEROBIC GLYCOLYSIS
G6P to Lactate
key enzyme LDH
FATES OF LACTATE
pyruvate to lactate = muscle
lactate transport = blood
lactate to pyruvate = heart
PFK 1
allosteric activator
ACTIVATORS
- AMP
- ADP
INHIBITORS
- ATP
- Citrate
Pyruvate kinase
ACTIVATOR
- Fructose 1,6 bisphosphate
INHIBITORS
- ATP
- Acetyl-CoA
ENERGETIC BALANCE OF ANAEROBIC GLYCOLYSIS
2 ATP
ENERGETIC BALANCE OF AEROBIC GLYCOLYSIS
5-7 ATP
ENERGETIC BALANCE OF ANAEROBIC GLYCOLYSIS IN RED BLOOD CELL
1 ATP
METABOLISM OF FRUCTOSE
cant be controlled because the control point, PFK-1, is skipped
ex. high fructose corn syrup
GLUCONEOGENESIS
synthesis of glucose from non carbohydrates sources (Lactate, Glycerol, Amino acids)
takes place in the liver and kidneys
GLUCONEOGENETIC ENZYMES
Phosphoenolpyruvate Carboxykinase
Phosphofructophosphatase 1
Glucose-6-Phosphatase
Phosphoenolpyruvate Carboxykinase
induced by glucocorticosteroid hormones and glucagon
PHOSPHOFRUCTOPHOSPHATASE 1
KEY ENZYME OF GLUCONEOGENESIS
competitive inhibitor
ACTIVATOR
- Citrate
INHIBITORS
- AMP
- Fructose 2,6 bisphosphate
Glucose-6-Phosphatase
Only present in liver, kidney and intestine