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Leucemias > Mieloma Múltiplo > Flashcards

Mieloma Múltiplo Flashcards

1
Q

Neoplasia de plasmócito =

A

MM

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2
Q

Quais as partes de uma gamaglobulina?

A

Parte variável
Cadeia leve
Cadeia pesada

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3
Q

Qual a clínica do MM?

A

Homem > 50 -60 anos negro

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4
Q

Quais principais queixas no MM?

A
  1. Dor lombar
  2. Palidez
  3. Astenia
  4. Anemia
  5. Oligúria
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5
Q

O que é o CARO?

A

Calcio
Anemia
Rim
Osso

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6
Q

C de CARO?

A

> 10,5 - 11

Ativa osteoclastos

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7
Q

A de CARO?

A

Anemia com Roleaux

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8
Q

O que decorre da anemia de Roleaux?

A

Diminui eritropoese

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9
Q

R de CARO?

A

Insuficiência renal com rim de mieloma e hipercalcemia

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10
Q

Como se manifesta o Rim de mieloma?

A

Insuficiência Renal
Proteína de Bence Jones causa a S Fanconi
Desidratação e proteinúria

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11
Q

Outras causas de IR no MM?

A

Amiloidose e lise tumoral

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12
Q

Mieloma osteoclerótico - significado do acrônimo POEMS?

A
  1. Polineuropatia simétrica
  2. Organomegalia
  3. Endocrinopatia
  4. Monoclonal
  5. Skin damage (lesao cutânea)
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13
Q

De qual material faço eletroforese de proteínas?

A

Sangue ± urina

[para detectar imunoglobulinas]

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14
Q

Qual o componente visto na eletroforese de proteínas?

A

M ≥ 3

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15
Q

Para que serve a imunofixação?

A

Para checar principal tipo de gamaglobulina

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16
Q

O que fazer quando aumento de cadeias leves livres?

A

Solicito [IgG, A, cadeia leve]

17
Q

Ql dg diferencial qdo nao tem CARO?

A

Mieloma indolente (smoldering)

18
Q

Qual principal característica de Macroglobulinemia de Waldenstrom?

A

Aumento de IgM e hiperviscosidade

19
Q

Como confirmo Macroglobulinemia de Waldenstrom?

A

MO com ≥ 10 % de plasmócitos
+ 1 do CARO ou
+ 1 biomarcador : ≥ 60% de plasmócitos em MO; cadeias leves ≥ ; > lesão focal em ressonância

20
Q

Proteína M< 3, plasmocitose medular < 10%, qual o achado?

A

Gamopatia monoclonal de significado indeterminado

Leucemias (6 decks)

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